2-{[2-(2-{2-[(2-{2-[(2-tert-butoxycarbonylamino-4-methyl-pentanoyl)-methyl-amino]-3-phenyl-propionylamino}-octanoyl)-methyl-amino]-propionyloxy}-propionylamino)-octanoyl]-methyl-amino}-4-methyl-pentanoic acid tert-butyl ester

Base Information

Chemical Name:2-{[2-(2-{2-[(2-{2-[(2-tert-butoxycarbonylamino-4-methyl-pentanoyl)-methyl-amino]-3-phenyl-propionylamino}-octanoyl)-methyl-amino]-propionyloxy}-propionylamino)-octanoyl]-methyl-amino}-4-methyl-pentanoic acid tert-butyl ester
CAS No.:438241-25-9
Molecular Formula:C₅₅H₉₄N₆O₁₁
Molecular Weight:1015.38
Hs Code.:

2-{[2-(2-{2-[(2-{2-[(2-<i>tert</i>-butoxycarbonylamino-4-methyl-pentanoyl)-methyl-amino]-3-phenyl-propionylamino}-octanoyl)-methyl-amino]-propionyloxy}-propionylamino)-octanoyl]-methyl-amino}-4-methyl-pentanoic acid <i>tert</i>-butyl ester

Synonyms:2-{[2-(2-{2-[(2-{2-[(2-tert-butoxycarbonylamino-4-methyl-pentanoyl)-methyl-amino]-3-phenyl-propionylamino}-octanoyl)-methyl-amino]-propionyloxy}-propionylamino)-octanoyl]-methyl-amino}-4-methyl-pentanoic acid tert-butyl ester

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Chemical Property of 2-{[2-(2-{2-[(2-{2-[(2-tert-butoxycarbonylamino-4-methyl-pentanoyl)-methyl-amino]-3-phenyl-propionylamino}-octanoyl)-methyl-amino]-propionyloxy}-propionylamino)-octanoyl]-methyl-amino}-4-methyl-pentanoic acid tert-butyl ester

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Technology Process of 2-{[2-(2-{2-[(2-{2-[(2-tert-butoxycarbonylamino-4-methyl-pentanoyl)-methyl-amino]-3-phenyl-propionylamino}-octanoyl)-methyl-amino]-propionyloxy}-propionylamino)-octanoyl]-methyl-amino}-4-methyl-pentanoic acid tert-butyl ester

There total 12 articles about 2-{[2-(2-{2-[(2-{2-[(2-tert-butoxycarbonylamino-4-methyl-pentanoyl)-methyl-amino]-3-phenyl-propionylamino}-octanoyl)-methyl-amino]-propionyloxy}-propionylamino)-octanoyl]-methyl-amino}-4-methyl-pentanoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 92211-95-5
N-tert-butoxycarbonyl-L-2-aminooctanoic acid

: 438241-25-9
2-{[2-(2-{2-[(2-{2-[(2-tert-butoxycarbonylamino-4-methyl-pentanoyl)-methyl-amino]-3-phenyl-propionylamino}-octanoyl)-methyl-amino]-propionyloxy}-propionylamino)-octanoyl]-methyl-amino}-4-methyl-pentanoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: EDCI; HOAt

2: HCl / ethyl acetate

3: EDCI; HOAt; 2,6-lutidine

4: aq. LiOH

5: DIAD; PPH₃

With 2,6-dimethylpyridine; hydrogenchloride; lithium hydroxide; 1-hydroxy-7-aza-benzotriazole; di-isopropyl azodicarboxylate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; In ethyl acetate; 5: Mitsunobu esterification;
DOI:10.1021/ja020166v

Reference yield:

: 42807-86-3
tert-butyl (2S)-4-methyl-2-(methylamino)pentanoate

: 438241-25-9
2-{[2-(2-{2-[(2-{2-[(2-tert-butoxycarbonylamino-4-methyl-pentanoyl)-methyl-amino]-3-phenyl-propionylamino}-octanoyl)-methyl-amino]-propionyloxy}-propionylamino)-octanoyl]-methyl-amino}-4-methyl-pentanoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: EDCI; HOAt; NaHCO₃

2: HCl / ethyl acetate

3: EDCI; HOAt; 2,6-lutidine

4: DIAD; PPH₃

With 2,6-dimethylpyridine; hydrogenchloride; 1-hydroxy-7-aza-benzotriazole; di-isopropyl azodicarboxylate; sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; In ethyl acetate; 4: Mitsunobu esterification;
DOI:10.1021/ja020166v

Reference yield:

: 438241-00-0
(S)-2-[((S)-2-tert-Butoxycarbonylamino-octanoyl)-methyl-amino]-propionic acid methyl ester

: 438241-25-9
2-{[2-(2-{2-[(2-{2-[(2-tert-butoxycarbonylamino-4-methyl-pentanoyl)-methyl-amino]-3-phenyl-propionylamino}-octanoyl)-methyl-amino]-propionyloxy}-propionylamino)-octanoyl]-methyl-amino}-4-methyl-pentanoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: HCl / ethyl acetate

2: EDCI; HOAt; 2,6-lutidine

3: aq. LiOH

4: DIAD; PPH₃

With 2,6-dimethylpyridine; hydrogenchloride; lithium hydroxide; 1-hydroxy-7-aza-benzotriazole; di-isopropyl azodicarboxylate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; In ethyl acetate; 4: Mitsunobu esterification;
DOI:10.1021/ja020166v