(R)-4-(1-(5-cyano-6-methylpyridin-2-yl)-5-cyclopentyl-4,5-dihydro-1H-pyrazol-3-yl)-2-methoxybenzoic acid

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Chemical Name:(R)-4-(1-(5-cyano-6-methylpyridin-2-yl)-5-cyclopentyl-4,5-dihydro-1H-pyrazol-3-yl)-2-methoxybenzoic acid
CAS No.:1246765-61-6
Molecular Formula:C₂₃H₂₄N₄O₃
Molecular Weight:404.469
Hs Code.:

Synonyms:(R)-4-(1-(5-cyano-6-methylpyridin-2-yl)-5-cyclopentyl-4,5-dihydro-1H-pyrazol-3-yl)-2-methoxybenzoic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-4-(1-(5-cyano-6-methylpyridin-2-yl)-5-cyclopentyl-4,5-dihydro-1H-pyrazol-3-yl)-2-methoxybenzoic acid

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (R)-4-(1-(5-cyano-6-methylpyridin-2-yl)-5-cyclopentyl-4,5-dihydro-1H-pyrazol-3-yl)-2-methoxybenzoic acid

There total 7 articles about (R)-4-(1-(5-cyano-6-methylpyridin-2-yl)-5-cyclopentyl-4,5-dihydro-1H-pyrazol-3-yl)-2-methoxybenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 851335-12-1
3-methoxy-4-p-carboxybenzeneboronic acid

: 1246765-10-5
(R)-4-(3-chloro-5-cyclopentyl-4,5-dihydro-1H-pyrazol-1-yl)-2-methylbenzonitrile

: 1246765-61-6
(R)-4-(1-(5-cyano-6-methylpyridin-2-yl)-5-cyclopentyl-4,5-dihydro-1H-pyrazol-3-yl)-2-methoxybenzoic acid

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; for 15h; Reflux; Inert atmosphere;

Reference yield:

: 1246765-23-0
6-(5-cyclopentyl-3-oxopyrazolidin-1-yl)-2-methylnicotinonitrile

: 1246765-61-6
(R)-4-(1-(5-cyano-6-methylpyridin-2-yl)-5-cyclopentyl-4,5-dihydro-1H-pyrazol-3-yl)-2-methoxybenzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: trichlorophosphate / acetonitrile / 2 h / 80 °C

2: chiralpak AD-H / methanol / Resolution of racemate; Supercritical conditions

3: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 15 h / Inert atmosphere; Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; trichlorophosphate; In methanol; 1,2-dimethoxyethane; acetonitrile; 3: |Suzuki Coupling;
DOI:10.1021/jm500206r

Reference yield:

: 1246765-24-1
6-(3-chloro-5-cyclopentyl-4,5-dihydro-1H-pyrazol-1-yl)-2-methylnicotinonitrile

: 1246765-61-6
(R)-4-(1-(5-cyano-6-methylpyridin-2-yl)-5-cyclopentyl-4,5-dihydro-1H-pyrazol-3-yl)-2-methoxybenzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: chiralpak AD-H / methanol / Resolution of racemate; Supercritical conditions

2: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 15 h / Inert atmosphere; Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In methanol; 1,2-dimethoxyethane; 2: |Suzuki Coupling;
DOI:10.1021/jm500206r