tert.-Butyl 3(R),5(S)-dihydroxy-6-[(2-p-fluorophenyl-4-p-fluorophenylthio-6-isopropyl)phenoxy]hexanoate

Base Information

Chemical Name:tert.-Butyl 3(R),5(S)-dihydroxy-6-[(2-p-fluorophenyl-4-p-fluorophenylthio-6-isopropyl)phenoxy]hexanoate
CAS No.:135054-70-5
Molecular Formula:C₃₁H₃₆F₂O₅S
Molecular Weight:558.687
Hs Code.:

Synonyms:tert.-Butyl 3(R),5(S)-dihydroxy-6-[(2-p-fluorophenyl-4-p-fluorophenylthio-6-isopropyl)phenoxy]hexanoate

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Chemical Property of tert.-Butyl 3(R),5(S)-dihydroxy-6-[(2-p-fluorophenyl-4-p-fluorophenylthio-6-isopropyl)phenoxy]hexanoate

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Technology Process of tert.-Butyl 3(R),5(S)-dihydroxy-6-[(2-p-fluorophenyl-4-p-fluorophenylthio-6-isopropyl)phenoxy]hexanoate

There total 5 articles about tert.-Butyl 3(R),5(S)-dihydroxy-6-[(2-p-fluorophenyl-4-p-fluorophenylthio-6-isopropyl)phenoxy]hexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 135054-69-2
{(4R,6S)-6-[4'-Fluoro-5-(4-fluoro-phenylsulfanyl)-3-isopropyl-biphenyl-2-yloxymethyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-acetic acid tert-butyl ester

: 135054-70-5
tert.-Butyl 3(R),5(S)-dihydroxy-6-[(2-p-fluorophenyl-4-p-fluorophenylthio-6-isopropyl)phenoxy]hexanoate

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; ethanol; at 25 ℃; for 24h;
DOI:10.1021/jm00114a004

Reference yield: 80.8%

: 135054-70-5
tert.-Butyl 3(R),5(S)-dihydroxy-6-[(2-p-fluorophenyl-4-p-fluorophenylthio-6-isopropyl)phenoxy]hexanoate

Guidance literature:

Reference yield:

: 131003-24-2
2-p-Fluorophenyl-4-p-fluorophenylthio-6-isopropylphenol

: 135054-70-5
tert.-Butyl 3(R),5(S)-dihydroxy-6-[(2-p-fluorophenyl-4-p-fluorophenylthio-6-isopropyl)phenoxy]hexanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 74 percent / K₂CO₃, 18-Crown-6 / hexamethylphosphoric acid triamide / 12 h / 60 - 85 °C

2: 81 percent / 2N HCl / ethanol; tetrahydrofuran / 24 h / 25 °C

With hydrogenchloride; 18-crown-6 ether; potassium carbonate; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; ethanol;
DOI:10.1021/jm00114a004