N-{trans-4-[2-(4-Thieno[2,3-c]pyridin-7-yl-piperazin-1-yl)-ethyl]-cyclohexyl}-propionamide

Base Information

Chemical Name:N-{trans-4-[2-(4-Thieno[2,3-c]pyridin-7-yl-piperazin-1-yl)-ethyl]-cyclohexyl}-propionamide
CAS No.:1354933-70-2
Molecular Formula:C₂₂H₃₂N₄OS
Molecular Weight:400.588
Hs Code.:

Synonyms:N-{trans-4-[2-(4-Thieno[2,3-c]pyridin-7-yl-piperazin-1-yl)-ethyl]-cyclohexyl}-propionamide

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Chemical Property of N-{trans-4-[2-(4-Thieno[2,3-c]pyridin-7-yl-piperazin-1-yl)-ethyl]-cyclohexyl}-propionamide

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Technology Process of N-{trans-4-[2-(4-Thieno[2,3-c]pyridin-7-yl-piperazin-1-yl)-ethyl]-cyclohexyl}-propionamide

There total 3 articles about N-{trans-4-[2-(4-Thieno[2,3-c]pyridin-7-yl-piperazin-1-yl)-ethyl]-cyclohexyl}-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: trans-4-[2-(4-thieno[2,3-c]pyridin-7-ylpiperazin-1-yl)ethyl]cyclohexylamine trihydrochloride

: 802294-64-0,79-09-4
propionic acid

: 1354933-70-2
N-{trans-4-[2-(4-Thieno[2,3-c]pyridin-7-yl-piperazin-1-yl)-ethyl]-cyclohexyl}-propionamide

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 18h;

Reference yield:

: 1354934-82-9
trans-{4-[2-(4-thieno[2,3-c]pyridin-7-ylpiperazin-1-yl)ethyl]cyclohexyl}carbamic acid tert-butyl ester

: 1354933-70-2
N-{trans-4-[2-(4-Thieno[2,3-c]pyridin-7-yl-piperazin-1-yl)-ethyl]-cyclohexyl}-propionamide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride; water / ethyl acetate; diethyl ether; methanol / 5 h / 20 °C

2: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 18 h / 20 °C

With hydrogenchloride; water; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In methanol; diethyl ether; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 215790-29-7
trans-2-(1-(4-(N-tert-butoxycarbonyl)amino)cyclohexyl)acetaldehyde

: 1354933-70-2
N-{trans-4-[2-(4-Thieno[2,3-c]pyridin-7-yl-piperazin-1-yl)-ethyl]-cyclohexyl}-propionamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic acid; sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane; methanol / 6 h / 20 °C

1.2: 16 h / 20 °C

2.1: hydrogenchloride; water / ethyl acetate; diethyl ether; methanol / 5 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 18 h / 20 °C

With hydrogenchloride; water; sodium tris(acetoxy)borohydride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; acetic acid; N-ethyl-N,N-diisopropylamine; In methanol; diethyl ether; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide;