trans-{4-[2-(4-thieno[2,3-c]pyridin-7-ylpiperazin-1-yl)ethyl]cyclohexyl}carbamic acid tert-butyl ester

Base Information

Chemical Name:trans-{4-[2-(4-thieno[2,3-c]pyridin-7-ylpiperazin-1-yl)ethyl]cyclohexyl}carbamic acid tert-butyl ester
CAS No.:1354934-82-9
Molecular Formula:C₂₄H₃₆N₄O₂S
Molecular Weight:444.641
Hs Code.:

Synonyms:trans-{4-[2-(4-thieno[2,3-c]pyridin-7-ylpiperazin-1-yl)ethyl]cyclohexyl}carbamic acid tert-butyl ester

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Chemical Property of trans-{4-[2-(4-thieno[2,3-c]pyridin-7-ylpiperazin-1-yl)ethyl]cyclohexyl}carbamic acid tert-butyl ester

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Technology Process of trans-{4-[2-(4-thieno[2,3-c]pyridin-7-ylpiperazin-1-yl)ethyl]cyclohexyl}carbamic acid tert-butyl ester

There total 1 articles about trans-{4-[2-(4-thieno[2,3-c]pyridin-7-ylpiperazin-1-yl)ethyl]cyclohexyl}carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 850734-85-9
7-piperazine-1-yl-thieno[2,3-c]pyridine hydrochloride

: 215790-29-7
trans-2-(1-(4-(N-tert-butoxycarbonyl)amino)cyclohexyl)acetaldehyde

: 1354934-82-9
trans-{4-[2-(4-thieno[2,3-c]pyridin-7-ylpiperazin-1-yl)ethyl]cyclohexyl}carbamic acid tert-butyl ester

Guidance literature:: 7-piperazine-1-yl-thieno[2,3-c]pyridine hydrochloride; trans-2-(1-(4-(N-tert-butoxycarbonyl)amino)cyclohexyl)acetaldehyde; With sodium tris(acetoxy)borohydride; acetic acid; In methanol; 1,2-dichloro-ethane; at 20 ℃; for 6h;

With sodium tris(acetoxy)borohydride; In methanol; 1,2-dichloro-ethane; at 20 ℃; for 16h;

With sodium hydrogencarbonate; sodium chloride; In methanol; water; ethyl acetate; 1,2-dichloro-ethane;

Reference yield: 59.0%

: 1354934-82-9
trans-{4-[2-(4-thieno[2,3-c]pyridin-7-ylpiperazin-1-yl)ethyl]cyclohexyl}carbamic acid tert-butyl ester

: trans-4-[2-(4-thieno[2,3-c]pyridin-7-ylpiperazin-1-yl)ethyl]cyclohexylamine trihydrochloride

Guidance literature:: With hydrogenchloride; water; In methanol; diethyl ether; ethyl acetate; at 20 ℃; for 5h;

Reference yield:

: 1354934-82-9
trans-{4-[2-(4-thieno[2,3-c]pyridin-7-ylpiperazin-1-yl)ethyl]cyclohexyl}carbamic acid tert-butyl ester

: 1354933-70-2
N-{trans-4-[2-(4-Thieno[2,3-c]pyridin-7-yl-piperazin-1-yl)-ethyl]-cyclohexyl}-propionamide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride; water / ethyl acetate; diethyl ether; methanol / 5 h / 20 °C

2: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 18 h / 20 °C

With hydrogenchloride; water; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In methanol; diethyl ether; ethyl acetate; N,N-dimethyl-formamide;