(alphaR)-4-Methoxy-3-(3-methoxypropoxy)-alpha-(1-methylethyl)benzenepropanal

Base Information

Chemical Name:(alphaR)-4-Methoxy-3-(3-methoxypropoxy)-alpha-(1-methylethyl)benzenepropanal
CAS No.:1027979-11-8
Molecular Formula:C₁₇H₂₆O₄
Molecular Weight:294.391
Hs Code.:
DSSTox Substance ID:DTXSID501158736

Synonyms:SCHEMBL14777605;DTXSID501158736;1027979-11-8

Suppliers and Price of (alphaR)-4-Methoxy-3-(3-methoxypropoxy)-alpha-(1-methylethyl)benzenepropanal

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (alphaR)-4-Methoxy-3-(3-methoxypropoxy)-alpha-(1-methylethyl)benzenepropanal

Chemical Property:

XLogP3:3.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:10
Exact Mass:294.18310931
Heavy Atom Count:21
Complexity:280

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)C(CC1=CC(=C(C=C1)OC)OCCCOC)C=O
Isomeric SMILES:CC(C)[C@@H](CC1=CC(=C(C=C1)OC)OCCCOC)C=O

Technology Process of (alphaR)-4-Methoxy-3-(3-methoxypropoxy)-alpha-(1-methylethyl)benzenepropanal

There total 18 articles about (alphaR)-4-Methoxy-3-(3-methoxypropoxy)-alpha-(1-methylethyl)benzenepropanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 172900-70-8
(R)-2-[4-methoxy-3-(3-methoxypropoxy)benzyl]-3-methylbutanol

: 1027979-11-8
(αR)-4-methoxy-3-(3-methoxypropoxy)-α-(1-methylethyl)benzenepropanal

Guidance literature:: (R)-2-[4-methoxy-3-(3-methoxypropoxy)benzyl]-3-methylbutanol; With oxalyl dichloride; dimethyl sulfoxide; In dichloromethane; at -78 ℃; for 1h; Inert atmosphere;

With triethylamine; In dichloromethane; at -78 - 0 ℃; for 2h;

Reference yield: 95.0%

: 1256556-40-7
(1S,3R,R)-3-(1-(4-methoxy-3-(3-methoxypropoxy)phenyl)-3-methylbutan-2-yl)-1-phenyl-2,3-dihydro-1H-naphtho[1,2-e][1,3]oxazine

: 1027979-11-8
(αR)-4-methoxy-3-(3-methoxypropoxy)-α-(1-methylethyl)benzenepropanal

Guidance literature:: With water; toluene-4-sulfonic acid; In tetrahydrofuran; ethyl acetate; at 20 ℃; for 13h;
DOI:10.1039/c0gc00013b

Reference yield:

: 172900-75-3
4-methoxy-3-(3-methoxypropoxy)benzaldehyde

: 1027979-11-8
(αR)-4-methoxy-3-(3-methoxypropoxy)-α-(1-methylethyl)benzenepropanal

Guidance literature:: Multi-step reaction with 6 steps

1.1: lithium diisopropyl amide / n-heptane; benzene; tetrahydrofuran / 1 h / -40 °C / Inert atmosphere

1.2: 2.25 h / -40 °C

2.1: camphor-10-sulfonic acid / toluene / Dean-Stark system; Reflux

3.1: hydrogen / palladium 10% on activated carbon / methanol / 18 h / 20 °C / 760.05 Torr

4.1: hydrogenchloride; 2-amino-2-hydroxymethyl-1,3-propanediol; water; HLAP / 48 h / 40 °C / Enzymatic reaction

4.2: 20 °C / pH 3.5

5.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 40 °C / Inert atmosphere

5.2: 20 °C

6.1: potassium carbonate; tetrabutyl-ammonium chloride; sodium hydrogencarbonate / N-chloro-succinimide; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / dichloromethane; water / 3 h / 20 °C

With hydrogenchloride; lithium aluminium tetrahydride; HLAP; tetrabutyl-ammonium chloride; water; hydrogen; sodium hydrogencarbonate; potassium carbonate; 2-amino-2-hydroxymethyl-1,3-propanediol; lithium diisopropyl amide; N-chloro-succinimide; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; palladium 10% on activated carbon; camphor-10-sulfonic acid; In tetrahydrofuran; methanol; n-heptane; dichloromethane; water; toluene; benzene;