172900-70-8

Basic information

• Product Name: Benzenepropanol, 4-methoxy-3-(3-methoxypropoxy)-b-(1-methylethyl)-, (bR)-
• Synonyms: Benzenepropanol, 4-methoxy-3-(3-methoxypropoxy)-b-(1-methylethyl)-, (bR)-;(R)-2-[3-(3-METHOXYPROPOXY)-4-METHOXYBENZYL]-3-METHYL-1-BUTANOL;(bR)-4-Methoxy-3-(3-methoxypropoxy)-beta-(1-methylethyl)benzenepropanol;(R)-2-[3-(3-Methoxypropoxy)-4-methoxybenzyl]-3-methylbutan-1-ol;1-Methoxy-2-(3-methoxypropoxy)-4-[(3-hydroxy-(2R)-isopropyl)propyl]benzene;(R)-2-[4-Methoxy-3-(3-Methoxy-propoxy)-benzyl]-3-Methyl-butan-1-ol;(R)-4-Methoxy-3-(3-Methoxypropoxy)-β-(1-Methylethyl)-benzenepropanol
• CAS NO: 172900-70-8
• Molecular Formula: C₁₇H₂₈O₄
• Molecular Weight: 296.4
• Product Categories: Drug Intermediates;Aromatics;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals;Aliskiren
• Mol File: 172900-70-8.mol
• Article Data: 24

Chemical Properties

• Boiling Point: 407.65 °C at 760 mmHg
• Flash Point: 200.34 °C
• Appearance: /
• Density: 1.020
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.496
• Solubility: Dichloromethane, Ethyl Acetate
• CAS DataBase Reference: Benzenepropanol, 4-methoxy-3-(3-methoxypropoxy)-b-(1-methylethyl)-, (bR)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenepropanol, 4-methoxy-3-(3-methoxypropoxy)-b-(1-methylethyl)-, (bR)-(172900-70-8)
• EPA Substance Registry System: Benzenepropanol, 4-methoxy-3-(3-methoxypropoxy)-b-(1-methylethyl)-, (bR)-(172900-70-8)

Safety Data

• Hazardous Substances Data: 172900-70-8(Hazardous Substances Data)

Usage

Uses

Intermediates in the preparation of Aliskiren.

InChI:InChI=1/C17H28O4/c1-13(2)15(12-18)10-14-6-7-16(20-4)17(11-14)21-9-5-8-19-3/h6-7,11,13,15,18H,5,8-10,12H2,1-4H3/t15-/m0/s1

Upstream product

• 172900-71-9 (R)-3-[4-methoxy-3-(3-methoxypropoxy)phenyl]-2-(1-methylethyl)propanoic acid 
• 324763-38-4 N-(2-hydroxy-1-methyl-2-phenyl-ethyl)-2-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-3,N-dimethyl-butyramide 
• 621-59-0 isovanillin 
• 145589-03-3 (R)-4-benzyl-3-(3-methylbutyryl)oxazolidin-2-one 
• 172900-75-3 4-methoxy-3-(3-methoxypropoxy)benzaldehyde 
• 172900-73-1 4-(bromomethyl)-1-methoxy-2-(3-methoxypropoxy)-benzene 
• 172900-74-2 [4-methoxy-3-(3-methoxypropoxy)-phenyl]methanol 
• 1381757-32-9 C₁₂H₁₇IO₃ 
• 108-12-3 isopentanoyl chloride 
• 1179062-77-1 4-chloromethyl-1-methoxy-2-(3-methoxypropoxy)-benzene 
• 324519-68-8 trans-(2S)-5-chloro-2-isopropyl-N,N-dimethyl-4-pentenamide 
• 324763-39-5 (R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane 
• 173336-76-0 4-bromo-1-methoxy-2-(3-methoxypropoxy)benzene 
• 138572-79-9 tert-butyldimethyl(3-methyl-2-methylenebutoxy)silane 

Downstream Products

• 324763-39-5 (R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane 
• 172900-83-3 (1S,3S)-{1-formyl-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl}-carbamic acid tert-butyl ester 
• 878276-62-1 (2S,4S)-2-tert-butoxycarbonylamino-4-[4-methoxy-3-(3-methoxypropoxy)benzyl]-5-methylhexanoic acid 
• 866030-36-6 [(1S,3S)-3-[4-Methoxy-3-(3-methoxy-propoxy)-benzyl]-1-(methoxy-methyl-carbamoyl)-4-methyl-pentyl]-carbamic acid tert-butyl ester 
• 866030-38-8 Benzyl-{(1S,3S)-1-formyl-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl}-carbamic acid tert-butyl ester 
• 866030-33-3 (2R,5S)-3,6-diethoxy-2-isopropyl-5-((S)-2-(4-methoxy-3-(3-methoxypropoxy)benzyl)-3-methylbutyl)-2,5-dihydropyrazine 
• 866030-35-5 tert-butyl {(1S,3S)-1-((2S,4S)-4-isopropyl-5-oxotetrahydrofuran-2-yl)-3-[4-methoxy-3-(3-methoxypropoxy)benzyl]-4-methylpentyl}carbamate 
• 866030-37-7 Benzyl-[(1S,3S)-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-1-(methoxy-methyl-carbamoyl)-4-methyl-pentyl]-carbamic acid tert-butyl ester 
• 866030-40-2 ((1S,2R,4S)-2-Hydroxy-4-hydroxymethyl-1-{(S)-2-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-3-methyl-butyl}-5-methyl-hexyl)-carbamic acid tert-butyl ester 
• 866030-34-4 ((1S,2S,4S)-2-hydroxy-4-hydroxymethyl-1-((S)-2-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-3-methyl-butyl)-5-methyl-hexyl)-carbamic acid tert-butyl ester 
• 172900-92-4 (1S,4S,2'S)-(4-benzyloxymethyl-2-hydroxy-1-{2'-[4-methoxy-3-(3-methoxypropoxy)benzyl]-3-methylbutyl}-5-methylhexyl)carbamic acid tert-butyl ester 
• 173338-07-3 tert-butyl (3S,5S,6S,8S)-8-(3-amino-2,2-dimethyl-3-oxopropylcarbamoyl)-6-hydroxy-3-(4-methoxy-3-(3-methoxypropoxy)benzyl)-2,9-dimethyldecan-5-ylcarbamate 
• 866030-39-9 Benzyl-((1S,2R,4S)-4-benzyloxymethyl-2-hydroxy-1-{(S)-2-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-3-methyl-butyl}-5-methyl-hexyl)-carbamic acid tert-butyl ester 
• 173334-57-1 (2S,4S,5S,7S)-5-Amino-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-8-methyl-nonanoic acid (2-carbamoyl-2-methyl-propyl)-amide 

Relevant articles and documents

Investigation of a kumada cross coupling reaction for large-scale production of (2 S, 7 R, E)-2-isopropyl-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)- N, N,8-trimethylnon-4-enamide

An investigation into the Kumada cross coupling reaction was conducted by developing a reliable, efficient procedure for the Grignard reagent and its subsequent cross coupling reaction. Safe Mg metal activation as well as a moisture-free system was create

Aliskiren intermediate preparation method

The present invention relates to the technical field of pharmaceutical preparation method, the preparation method of the existing long reaction time, the problem of low yield, provides a aliskiren preparation method, comprises the following steps: S1, 1st intermediate preparation: the raw material is dissolved in a solvent, adding sodium hypochlorite and sodium bisulfite reaction, shall be 1st intermediate; S2, intermediate in the preparation of 2nd: to the 1st intermediate dropping 4 - bromo - 1 - methoxy - 2 - (3 - methoxy third oxygen radical) benzene, tetrahydrofuran solution, adding low [...] catalyst, to obtain the 2nd intermediate; S3, aliskiren intermediate preparation: will be soluble in ethyl acetate in the 2nd intermediate, then adding water, nitrogen replacement 3 times, the hydrogen replaced 3 times after adding the hydrogen hydrogenation reaction, to obtain the product. By adding low deuterium water as a catalyst, help to accelerate the step S2 of the reaction rate, the reaction time is shortened, while at the same time help to improve the step S2 in the reaction yield, and then make the total reaction yield can be improved.

Convergent Synthesis of the Renin Inhibitor Aliskiren Based on C5-C6 Disconnection and CO2H-NH2 Equivalence

A novel synthesis of the renin inhibitor aliskiren based on an unprecedented disconnection between C5 and C6 was developed, in which the C5 carbon acts as a nucleophile and the amino group is introduced by a Curtius rearrangement, which follows a simultaneous stereocontrolled generation of the C4 and C5 stereogenic centers by an asymmetric hydrogenation. Operational simplicity, step economy, and a good overall yield makes this synthesis amenable to manufacture on scale.