ethyl 5-(2-(bis(dimethylamino)phosphoryloxy)-4-(ethoxycarbonyl)phenyl)furan-2-carboxylate

Base Information

Chemical Name:ethyl 5-(2-(bis(dimethylamino)phosphoryloxy)-4-(ethoxycarbonyl)phenyl)furan-2-carboxylate
CAS No.:1425194-03-1
Molecular Formula:C₂₀H₂₇N₂O₇P
Molecular Weight:438.417
Hs Code.:

Synonyms:ethyl 5-(2-(bis(dimethylamino)phosphoryloxy)-4-(ethoxycarbonyl)phenyl)furan-2-carboxylate

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Chemical Property of ethyl 5-(2-(bis(dimethylamino)phosphoryloxy)-4-(ethoxycarbonyl)phenyl)furan-2-carboxylate

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Technology Process of ethyl 5-(2-(bis(dimethylamino)phosphoryloxy)-4-(ethoxycarbonyl)phenyl)furan-2-carboxylate

There total 2 articles about ethyl 5-(2-(bis(dimethylamino)phosphoryloxy)-4-(ethoxycarbonyl)phenyl)furan-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 6132-37-2
ethyl 5-bromofuran-2-carboxylate

: (2-(bis(dimethylamino)phosphoryloxy)-4-(ethoxycarbonyl)phenyl)zinc pivalate

: 1425194-03-1
ethyl 5-(2-(bis(dimethylamino)phosphoryloxy)-4-(ethoxycarbonyl)phenyl)furan-2-carboxylate

Guidance literature:: (2-(bis(dimethylamino)phosphoryloxy)-4-(ethoxycarbonyl)phenyl)zinc pivalate; With palladium diacetate; XPhos; In tetrahydrofuran; at 25 ℃; for 0.0333333h; Inert atmosphere; Schlenk technique;

ethyl 5-bromofuran-2-carboxylate; In tetrahydrofuran; at 50 ℃; for 12h; Inert atmosphere; Schlenk technique;
DOI:10.1002/anie.201204526

Reference yield:

: 501649-30-5
ethyl 3-(N,N,N',N'-tetramethyldiamidophosphoryloxy)benzoate

: 1425194-03-1
ethyl 5-(2-(bis(dimethylamino)phosphoryloxy)-4-(ethoxycarbonyl)phenyl)furan-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 2,2,6,6-tetramethylpiperidinylmagnesium chloride lithium chloride complex / tetrahydrofuran / 3 h / 0 °C / Inert atmosphere; Schlenk technique

1.2: 0.25 h / 0 - 25 °C / Inert atmosphere; Schlenk technique

2.1: palladium diacetate; XPhos / tetrahydrofuran / 0.03 h / 25 °C / Inert atmosphere; Schlenk technique

2.2: 12 h / 50 °C / Inert atmosphere; Schlenk technique

With 2,2,6,6-tetramethylpiperidinylmagnesium chloride lithium chloride complex; palladium diacetate; XPhos; In tetrahydrofuran; 2.1: |Negishi Coupling / 2.2: |Negishi Coupling;
DOI:10.1002/anie.201204526