(S)-4-((2-(1-(tert-butoxycarbonyl)pyrrolidin-2-yl)-1H-imidazol-5-yl)ethynyl)phenylboronic acid

Base Information

Chemical Name:(S)-4-((2-(1-(tert-butoxycarbonyl)pyrrolidin-2-yl)-1H-imidazol-5-yl)ethynyl)phenylboronic acid
CAS No.:1307304-40-0
Molecular Formula:C₂₀H₂₄BN₃O₄
Molecular Weight:381.239
Hs Code.:

Synonyms:(S)-4-((2-(1-(tert-butoxycarbonyl)pyrrolidin-2-yl)-1H-imidazol-5-yl)ethynyl)phenylboronic acid

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Chemical Property of (S)-4-((2-(1-(tert-butoxycarbonyl)pyrrolidin-2-yl)-1H-imidazol-5-yl)ethynyl)phenylboronic acid

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Technology Process of (S)-4-((2-(1-(tert-butoxycarbonyl)pyrrolidin-2-yl)-1H-imidazol-5-yl)ethynyl)phenylboronic acid

There total 4 articles about (S)-4-((2-(1-(tert-butoxycarbonyl)pyrrolidin-2-yl)-1H-imidazol-5-yl)ethynyl)phenylboronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1228552-62-2
(S)-2-(4-iodo-1H-imidazol-2-yl)pyrrolidine-1-carboxylic acid tert-butyl ester

: (4-dihydroxyborophenyl)acetylene

: 1307304-40-0
(S)-4-((2-(1-(tert-butoxycarbonyl)pyrrolidin-2-yl)-1H-imidazol-5-yl)ethynyl)phenylboronic acid

Guidance literature:: With copper(l) iodide; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 60 ℃; Inert atmosphere; Sealed tube;

Reference yield:

: 69610-41-9,117625-90-8
Boc-L-Pro-H

: 1307304-40-0
(S)-4-((2-(1-(tert-butoxycarbonyl)pyrrolidin-2-yl)-1H-imidazol-5-yl)ethynyl)phenylboronic acid

Guidance literature:: Multi-step reaction with 4 steps

1: ammonium hydroxide / water; methanol / 19 h / 20 °C

2: iodine; sodium carbonate / 1,4-dioxane; water / 16 h / 20 °C / Darkness

3: sodium sulfite / ethanol; water / 20 h / 90 - 100 °C

4: triethylamine; copper(l) iodide / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 60 °C / Inert atmosphere; Sealed tube

With ammonium hydroxide; copper(l) iodide; iodine; sodium carbonate; triethylamine; sodium sulfite; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; methanol; ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 1007882-58-7,1332326-40-5
(S)-tert-butyl 2-(1H-imidazol-2-yl)pyrrolidine-1-carboxylate

: 1307304-40-0
(S)-4-((2-(1-(tert-butoxycarbonyl)pyrrolidin-2-yl)-1H-imidazol-5-yl)ethynyl)phenylboronic acid

Guidance literature:: Multi-step reaction with 3 steps

1: iodine; sodium carbonate / 1,4-dioxane; water / 16 h / 20 °C / Darkness

2: sodium sulfite / ethanol; water / 20 h / 90 - 100 °C

3: triethylamine; copper(l) iodide / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 60 °C / Inert atmosphere; Sealed tube

With copper(l) iodide; iodine; sodium carbonate; triethylamine; sodium sulfite; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide;