(2S)-2-((Z)-3-Iodo-2-propenyl)-1-<2-(3,4-dimethoxyphenyl)ethyl>pyrrolidine-2-carbaldehyde

Base Information

Chemical Name:(2S)-2-((Z)-3-Iodo-2-propenyl)-1-<2-(3,4-dimethoxyphenyl)ethyl>pyrrolidine-2-carbaldehyde
CAS No.:160360-21-4
Molecular Formula:C₁₈H₂₄INO₃
Molecular Weight:429.298
Hs Code.:

Synonyms:(2S)-2-((Z)-3-Iodo-2-propenyl)-1-<2-(3,4-dimethoxyphenyl)ethyl>pyrrolidine-2-carbaldehyde

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Chemical Property of (2S)-2-((Z)-3-Iodo-2-propenyl)-1-<2-(3,4-dimethoxyphenyl)ethyl>pyrrolidine-2-carbaldehyde

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Technology Process of (2S)-2-((Z)-3-Iodo-2-propenyl)-1-<2-(3,4-dimethoxyphenyl)ethyl>pyrrolidine-2-carbaldehyde

There total 10 articles about (2S)-2-((Z)-3-Iodo-2-propenyl)-1-<2-(3,4-dimethoxyphenyl)ethyl>pyrrolidine-2-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1026068-36-9
[(S)-1-[2-(3,4-Dimethoxy-phenyl)-ethyl]-2-((Z)-3-iodo-allyl)-pyrrolidin-2-yl]-methanol

: 160360-21-4
(2S)-2-((Z)-3-Iodo-2-propenyl)-1-<2-(3,4-dimethoxyphenyl)ethyl>pyrrolidine-2-carbaldehyde

Guidance literature:: With pyridine-SO₃ complex; triethylamine; In dimethyl sulfoxide; for 3h; Yield given; Ambient temperature;
DOI:10.1021/jo00106a023

Reference yield:

: 132564-23-9
2-(3,4-Dimethoxyphenyl)ethyl alcohol p-nitrobenzenesulfonate ester

: 160360-21-4
(2S)-2-((Z)-3-Iodo-2-propenyl)-1-<2-(3,4-dimethoxyphenyl)ethyl>pyrrolidine-2-carbaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1: i-Pr₂NEt / acetonitrile / 12 h / Heating

2: LiAlH₄ / tetrahydrofuran / 6 h / -50 °C

3: SO₃*Py, Et₃N / dimethylsulfoxide / 3 h / Ambient temperature

With lithium aluminium tetrahydride; pyridine-SO₃ complex; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dimethyl sulfoxide; acetonitrile;
DOI:10.1021/jo00106a023

Reference yield:

: 1026124-76-4
(S)-2-((Z)-3-Iodo-allyl)-pyrrolidine-2-carboxylic acid

: 160360-21-4
(2S)-2-((Z)-3-Iodo-2-propenyl)-1-<2-(3,4-dimethoxyphenyl)ethyl>pyrrolidine-2-carbaldehyde

Guidance literature:: Multi-step reaction with 6 steps

1: aq. NaOH / dioxane / 24 h / Ambient temperature

2: methanol; diethyl ether

3: CF₃CO₂H / CH₂Cl₂ / 2 h / Ambient temperature

4: i-Pr₂NEt / acetonitrile / 12 h / Heating

5: LiAlH₄ / tetrahydrofuran / 6 h / -50 °C

6: SO₃*Py, Et₃N / dimethylsulfoxide / 3 h / Ambient temperature

With sodium hydroxide; lithium aluminium tetrahydride; pyridine-SO₃ complex; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; dichloromethane; dimethyl sulfoxide; acetonitrile;
DOI:10.1021/jo00106a023