5-benzyloxycarbonyl-1-(chloromethyl)-1,2-dihydro-3-[(5,6,7-trimethoxy-1H-indol-2-yl)carbonyl]-3H-furano[2,3-e]indoline

Base Information

Chemical Name:5-benzyloxycarbonyl-1-(chloromethyl)-1,2-dihydro-3-[(5,6,7-trimethoxy-1H-indol-2-yl)carbonyl]-3H-furano[2,3-e]indoline
CAS No.:494868-88-1
Molecular Formula:C₃₀H₂₇ClN₂O₆
Molecular Weight:547.007
Hs Code.:

Synonyms:5-benzyloxycarbonyl-1-(chloromethyl)-1,2-dihydro-3-[(5,6,7-trimethoxy-1H-indol-2-yl)carbonyl]-3H-furano[2,3-e]indoline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-benzyloxycarbonyl-1-(chloromethyl)-1,2-dihydro-3-[(5,6,7-trimethoxy-1H-indol-2-yl)carbonyl]-3H-furano[2,3-e]indoline

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 5-benzyloxycarbonyl-1-(chloromethyl)-1,2-dihydro-3-[(5,6,7-trimethoxy-1H-indol-2-yl)carbonyl]-3H-furano[2,3-e]indoline

There total 12 articles about 5-benzyloxycarbonyl-1-(chloromethyl)-1,2-dihydro-3-[(5,6,7-trimethoxy-1H-indol-2-yl)carbonyl]-3H-furano[2,3-e]indoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 128781-07-7
5,6,7-trimethoxy-1H-indole-2-carboxylic acid

: 4-benzyloxy-8-chloromethyl-7,8-dihydro-6H-1-oxa-6-aza-as-indacene

: 494868-88-1
5-benzyloxycarbonyl-1-(chloromethyl)-1,2-dihydro-3-[(5,6,7-trimethoxy-1H-indol-2-yl)carbonyl]-3H-furano[2,3-e]indoline

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1016/j.tetlet.2014.04.062

Reference yield: 83.0%

: 128781-07-7
5,6,7-trimethoxy-1H-indole-2-carboxylic acid

: 494868-86-9
5-benzyloxy-3-(tert-butoxycarbonyl)-1-chloromethyl-1,2-dihydro-3H-furano[2,3-e]indole

: 494868-88-1
5-benzyloxycarbonyl-1-(chloromethyl)-1,2-dihydro-3-[(5,6,7-trimethoxy-1H-indol-2-yl)carbonyl]-3H-furano[2,3-e]indoline

Guidance literature:: 5-benzyloxy-3-(tert-butoxycarbonyl)-1-chloromethyl-1,2-dihydro-3H-furano[2,3-e]indole; With hydrogenchloride; In tetrahydrofuran; at 20 ℃;

5,6,7-trimethoxy-1H-indole-2-carboxylic acid; With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1039/c4ob00842a

Reference yield:

: 4-benzyloxy-7-bromo-6-[N-(3-chloro-2-propenyl)-N-(tert-butyloxycarbonyl)amino]benzofuran

: 494868-88-1
5-benzyloxycarbonyl-1-(chloromethyl)-1,2-dihydro-3-[(5,6,7-trimethoxy-1H-indol-2-yl)carbonyl]-3H-furano[2,3-e]indoline

Guidance literature:: Multi-step reaction with 3 steps

1: 40 percent / AIBN; nBu₃SnH / toluene / 2 h / 90 °C

2: conc. HCl / tetrahydrofuran / 4 h / 20 °C

3: 150 mg / EDCI / dimethylformamide / 72 h

With hydrogenchloride; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;
DOI:10.1016/S0968-0896(02)00157-8