1-[4-(methoxycarbonyl)-3-methylphenyl]-4-[(3,3,3-trifluoropropyl)amino]-1H-benzimidazole-6-carboxylic acid

Base Information

Chemical Name:1-[4-(methoxycarbonyl)-3-methylphenyl]-4-[(3,3,3-trifluoropropyl)amino]-1H-benzimidazole-6-carboxylic acid
CAS No.:1401450-89-2
Molecular Formula:C₂₀H₁₈F₃N₃O₄
Molecular Weight:421.376
Hs Code.:

Synonyms:1-[4-(methoxycarbonyl)-3-methylphenyl]-4-[(3,3,3-trifluoropropyl)amino]-1H-benzimidazole-6-carboxylic acid

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Chemical Property of 1-[4-(methoxycarbonyl)-3-methylphenyl]-4-[(3,3,3-trifluoropropyl)amino]-1H-benzimidazole-6-carboxylic acid

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Technology Process of 1-[4-(methoxycarbonyl)-3-methylphenyl]-4-[(3,3,3-trifluoropropyl)amino]-1H-benzimidazole-6-carboxylic acid

There total 8 articles about 1-[4-(methoxycarbonyl)-3-methylphenyl]-4-[(3,3,3-trifluoropropyl)amino]-1H-benzimidazole-6-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.0%

: 201230-82-2
carbon monoxide

: 1401449-77-1
methyl 4-{6-bromo-4-[(3,3,3-trifluoropropyl)amino]-1H-benzimidazol-1-yl}-2-methylbenzoate

: 149507-26-6
3-fluoro-4-methoxy-phenylboronic acid

: 1401450-89-2
1-[4-(methoxycarbonyl)-3-methylphenyl]-4-[(3,3,3-trifluoropropyl)amino]-1H-benzimidazole-6-carboxylic acid

: 1401450-88-1
methyl 4-{6-(3-fluoro-4-methoxybenzoyl)-4-[(3,3,3-trifluoropropyl)amino]-1H-benzimidazol-1-yl}-2-methylbenzoate

Guidance literature:: With palladium diacetate; N-ethyl-N,N-diisopropylamine; catacxium A; In toluene; at 100 ℃; under 10501.1 Torr;

Reference yield:

: 606-22-4
2,6-dinitroaniline

: 1401450-89-2
1-[4-(methoxycarbonyl)-3-methylphenyl]-4-[(3,3,3-trifluoropropyl)amino]-1H-benzimidazole-6-carboxylic acid

: 1401450-88-1
methyl 4-{6-(3-fluoro-4-methoxybenzoyl)-4-[(3,3,3-trifluoropropyl)amino]-1H-benzimidazol-1-yl}-2-methylbenzoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: bromine; acetic acid

2.1: hydrogenchloride; tin(II) chloride dihdyrate / water / -20 - 20 °C

2.2: pH 10

3.1: hydrogenchloride / 20 °C / Reflux

3.2: pH 8

4.1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 23 °C

4.2: 3 °C

5.1: pyridine N-oxide; pyridine; copper diacetate / dichloromethane / 60 h / 23 °C

6.1: N-ethyl-N,N-diisopropylamine; palladium diacetate; catacxium A / toluene / 100 °C / 10501.1 Torr

With pyridine; pyridine N-oxide; hydrogenchloride; tin(II) chloride dihdyrate; bromine; copper diacetate; palladium diacetate; sodium tris(acetoxy)borohydride; acetic acid; N-ethyl-N,N-diisopropylamine; catacxium A; In dichloromethane; water; toluene;

Reference yield:

: 1360899-50-8
6-bromo-1H-1,3-benzodiazol-4-amine

: 1401450-89-2
1-[4-(methoxycarbonyl)-3-methylphenyl]-4-[(3,3,3-trifluoropropyl)amino]-1H-benzimidazole-6-carboxylic acid

: 1401450-88-1
methyl 4-{6-(3-fluoro-4-methoxybenzoyl)-4-[(3,3,3-trifluoropropyl)amino]-1H-benzimidazol-1-yl}-2-methylbenzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 23 °C

1.2: 3 °C

2.1: pyridine N-oxide; pyridine; copper diacetate / dichloromethane / 60 h / 23 °C

3.1: N-ethyl-N,N-diisopropylamine; palladium diacetate; catacxium A / toluene / 100 °C / 10501.1 Torr

With pyridine; pyridine N-oxide; copper diacetate; palladium diacetate; sodium tris(acetoxy)borohydride; acetic acid; N-ethyl-N,N-diisopropylamine; catacxium A; In dichloromethane; toluene;