1,1-dimethylethyl {(1R)-methyl-2-[(4-{[2-methyl-5-(methyloxy)phenyl]oxy}phenyl)amino]-2-oxoethyl}carbamate

Base Information

Chemical Name:1,1-dimethylethyl {(1R)-methyl-2-[(4-{[2-methyl-5-(methyloxy)phenyl]oxy}phenyl)amino]-2-oxoethyl}carbamate
CAS No.:1311137-82-2
Molecular Formula:C₂₂H₂₈N₂O₅
Molecular Weight:400.475
Hs Code.:

Synonyms:1,1-dimethylethyl {(1R)-methyl-2-[(4-{[2-methyl-5-(methyloxy)phenyl]oxy}phenyl)amino]-2-oxoethyl}carbamate

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Chemical Property of 1,1-dimethylethyl {(1R)-methyl-2-[(4-{[2-methyl-5-(methyloxy)phenyl]oxy}phenyl)amino]-2-oxoethyl}carbamate

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Technology Process of 1,1-dimethylethyl {(1R)-methyl-2-[(4-{[2-methyl-5-(methyloxy)phenyl]oxy}phenyl)amino]-2-oxoethyl}carbamate

There total 6 articles about 1,1-dimethylethyl {(1R)-methyl-2-[(4-{[2-methyl-5-(methyloxy)phenyl]oxy}phenyl)amino]-2-oxoethyl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3744-87-4,7764-95-6,15761-38-3
Boc-(R)-Ala

: 1311137-81-1
4-{[2-methyl-5-(methyloxy)phenyl]oxy}aniline

: 1311137-82-2
1,1-dimethylethyl {(1R)-methyl-2-[(4-{[2-methyl-5-(methyloxy)phenyl]oxy}phenyl)amino]-2-oxoethyl}carbamate

Guidance literature:: Boc-(R)-Ala; With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 0.25h; Inert atmosphere;

4-{[2-methyl-5-(methyloxy)phenyl]oxy}aniline; In N,N-dimethyl-formamide; at 60 ℃; for 1.5h; Inert atmosphere;

Reference yield:

: 17484-36-5
4-Methyl-3-nitroanisole

: 1311137-82-2
1,1-dimethylethyl {(1R)-methyl-2-[(4-{[2-methyl-5-(methyloxy)phenyl]oxy}phenyl)amino]-2-oxoethyl}carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogen / palladium 10% on activated carbon / methanol / 20 °C

2.1: sodium nitrite; sulfuric acid / 0 - 50 °C

3.1: potassium carbonate / acetonitrile / 5 h / Reflux

4.1: hydrogen / palladium 10% on activated carbon / methanol / 20 °C

5.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.25 h / 20 °C / Inert atmosphere

5.2: 1.5 h / 60 °C / Inert atmosphere

With sulfuric acid; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; sodium nitrite; palladium 10% on activated carbon; In methanol; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 50868-72-9
5-methoxy-o-toluidine

: 1311137-82-2
1,1-dimethylethyl {(1R)-methyl-2-[(4-{[2-methyl-5-(methyloxy)phenyl]oxy}phenyl)amino]-2-oxoethyl}carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium nitrite; sulfuric acid / 0 - 50 °C

2.1: potassium carbonate / acetonitrile / 5 h / Reflux

3.1: hydrogen / palladium 10% on activated carbon / methanol / 20 °C

4.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.25 h / 20 °C / Inert atmosphere

4.2: 1.5 h / 60 °C / Inert atmosphere

With sulfuric acid; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; sodium nitrite; palladium 10% on activated carbon; In methanol; N,N-dimethyl-formamide; acetonitrile;