8-Quinolinamine,5-methyl-(9CI)

Base Information

• Chemical Name: 8-Quinolinamine,5-methyl-(9CI)
• CAS No.: 85656-64-0
• Molecular Formula: C10H10 N2
• Molecular Weight: 158.203
• Hs Code.: 2933499090
• Mol file: 85656-64-0.mol

Synonyms:8-Quinolinamine,5-methyl-(9CI)

Chemical Property of 8-Quinolinamine,5-methyl-(9CI)

Chemical Property:

• Melting Point: 46-47 °C
• Boiling Point: 327.5±27.0 °C(Predicted)
• PKA: 4.34±0.12(Predicted)
• PSA: 38.91000
• Density: 1.169±0.06 g/cm3(Predicted)
• LogP: 2.70660
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

5-Methylquinolin-8-amine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 8-Quinolinamine,5-methyl-(9CI)

There total 5 articles about 8-Quinolinamine,5-methyl-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

5-methyl-8-nitroquinoline (65745-69-9) → 5-methyl-8-aminoquinoline (85656-64-0)

Guidance literature:

With palladium on carbon; hydrogen; In ethyl acetate; Sealed tube;

DOI:10.1002/adsc.201600161

Reference yield:

N-(5-methyl-2-nitrophenyl)acetamide (7418-36-2) → 5-methyl-8-aminoquinoline (85656-64-0)

Guidance literature:

Multi-step reaction with 2 steps

1: picric acid; iron (II)-sulfate; boric acid / und Schwefelsaeure

2: iron; aqueous HCl

With hydrogenchloride; boric acid; iron; 2,4,6-Trinitrophenol; iron(II) sulfate;

Reference yield:

5-methylquinoline (7661-55-4) → 5-methyl-8-aminoquinoline (85656-64-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 69 percent / conc. sulphuric acid, fuming nitric acid, 7-methylquinoline / 0.08 h / Ambient temperature

2: hydrogen / 5percent palladium-charcoal / ethanol / 3 h / 1520 Torr / Ambient temperature

With 7-methylquinoline; sulfuric acid; hydrogen; nitric acid; palladium on activated charcoal; In ethanol;

upstream raw materials:

5-methyl-8-nitroquinoline

5-methylquinoline

N-(5-methyl-2-nitrophenyl)acetamide

5-methyl-2-nitroaniline

Downstream raw materials:

2,4,6-Trimethyl-benzenesulfonate1-amino-8-formylamino-5-methyl-quinolinium;

Refernces

• 1、 Whiteoak, Christopher J.,Planas, Oriol,Company, Anna,Ribas, Xavi. "A First Example of Cobalt-Catalyzed Remote C H Functionalization of 8-Aminoquinolines Operating through a Single Electron Transfer Mechanism". supporting information. p. 1679 - 1688. Retrieved 2016/10/13.
• 2、 Ikeda, Masazumi,Yamagishi, Masafumi,Bayomi, Said M. M.,Miki, Yasuyoshi,Sumida, Yoshio,Tamura, Yasumitsu. "Synthesis and Some Properties of A New Class of Six Membered Heteroaromatic Betains, 3H-Pyridobenzotriazin-4-ylium-3-ides". . p. 349 - 354. Retrieved 2007/10/02.