7418-36-2

Basic information

• Product Name: N-(5-methyl-2-nitrophenyl)acetamide
• CAS NO: 7418-36-2
• Molecular Formula: C₉H₁₀N₂O₃
• Molecular Weight: 194.1873
• Mol File: 7418-36-2.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 395.8°C at 760 mmHg
• Flash Point: 193.2°C
• Density: 1.289g/cm³
• Vapor Pressure: 1.79E-06mmHg at 25°C
• Refractive Index: 1.605
• CAS DataBase Reference: N-(5-methyl-2-nitrophenyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(5-methyl-2-nitrophenyl)acetamide(7418-36-2)
• EPA Substance Registry System: N-(5-methyl-2-nitrophenyl)acetamide(7418-36-2)

Safety Data

• Hazardous Substances Data: 7418-36-2(Hazardous Substances Data)

Usage

General Description

N-(5-methyl-2-nitrophenyl)acetamide is a chemical compound commonly used in the pharmaceutical industry. It is classified as an acetamide derivative, containing a nitro group attached to a phenyl ring. This chemical has potential applications as an intermediate in the synthesis of various drugs and pharmaceuticals. It may also possess biological activity and could potentially be used as a building block in the development of new medications. Additionally, it may be used in research and development efforts aimed at understanding its potential therapeutic properties. Overall, N-(5-methyl-2-nitrophenyl)acetamide has a broad range of potential uses and applications, particularly in the pharmaceutical and biomedical fields.

Upstream product

• 537-92-8 3-Methylacetanilide 
• 108-24-7 acetic anhydride 
• 108-44-1 1-amino-3-methylbenzene 
• 7697-37-2 nitric acid 
• 64-19-7 acetic acid 
• 578-46-1 5-methyl-2-nitroaniline 
• 75-36-5 acetyl chloride 
• 25917-89-9 4-amino-3-nitro-6-methylaniline 

Downstream Products

• 29547-08-8 5-methyl-2-nitro-biphenyl 
• 54002-27-6 3-acetylamino-4-nitro-benzoic acid 
• 85656-64-0 5-methyl-8-aminoquinoline 
• 2963-65-7 5-methyl-2-phenyl-1H-1,3-benzimidazole 
• 1792-41-2 2,5-dimethylbenzimidazole 
• 43154-38-7 acetic acid-(2-amino-5-methyl-anilide) 
• 578-46-1 5-methyl-2-nitroaniline 
• 65745-69-9 5-methyl-8-nitroquinoline 
• 6968-22-5 3-amino-4-nitrobenzoic acid 
• 129354-65-0 6-Methyl-1-acetylbenzotriazole 

Relevant articles and documents

Transition-metal-free mono- or dinitration of protected anilines

An amide-assisted arene nitration is presented, and both mono- and dinitration of protected anilines could be effected by using NaNO2 and NaNO3 as the mono- and bisnitrating agents, respectively. This divergent synthesis is transition-metal- and acid-free, and features a broad substrate scope, low cost, and ortho–para selectivity.

Regioselective ortho-nitration of N-phenyl carboxamides and primary anilines using bismuth nitrate/acetic anhydride

An efficient and one-pot synthetic method for the regioselective ortho-nitration of the N-phenyl carboxamides and primary anilines has been developed by using bismuth nitrate and acetic anhydride as the nitrating reagents. Reaction proceeds at room temperature and results in corresponding ortho-nitrated products in moderate to excellent yields. This method provides an operationally simple, regioselective, and efficient access to synthesize o-nitro anilines under the mild conditions.

Ozone-mediated Reaction of Anilides and Phenyl Esters with Nitrogen Dioxide: Enhanced Ortho-reactivity and Mechanistic Implications

In the presence of ozone, anilides 1 can be nitrated rapidly with nitrogen dioxide in chloroform at 0 deg C to give a high proportion of ortho-nitro derivatives (ortho:para = 1.2-4.4) in good yields.The phenyl esters 15 can be similarly nitrated on the aromatic ring without significant cleavage of the ester bond, giving a mixture of isomeric nitro derivatives in which the ortho-isomer predominantes (ortho:para = 1.1-1.5).The oridin of the enhanced ortho reactivity is discussed in terms of an electron-transfer process involving the nitrogen trioxide as initial electrophile.