4-(tert-butyl)-N-(4-(thiophen-2-yl)phenyl)-N-(p-tolyl)aniline

Base Information

• Chemical Name: 4-(tert-butyl)-N-(4-(thiophen-2-yl)phenyl)-N-(p-tolyl)aniline
• CAS No.: 1122400-35-4
• Molecular Formula: C₂₇H₂₇NS
• Molecular Weight: 397.584
• Mol file: 1122400-35-4.mol

Synonyms:4-(tert-butyl)-N-(4-(thiophen-2-yl)phenyl)-N-(p-tolyl)aniline

Chemical Property of 4-(tert-butyl)-N-(4-(thiophen-2-yl)phenyl)-N-(p-tolyl)aniline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(tert-butyl)-N-(4-(thiophen-2-yl)phenyl)-N-(p-tolyl)aniline

There total 5 articles about 4-(tert-butyl)-N-(4-(thiophen-2-yl)phenyl)-N-(p-tolyl)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

thiophene boronic acid (6165-68-0) + 4-bromo-N-(4-(tert-butyl)phenyl)-N-(p-tolyl)aniline (1122400-34-3) → 4-(tert-butyl)-N-(4-(thiophen-2-yl)phenyl)-N-(p-tolyl)aniline (1122400-35-4)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In tetrahydrofuran; water; for 24h; Inert atmosphere; Reflux; Darkness;

Reference yield: 60.0%

4-bromo-N-(4-(tert-butyl)phenyl)-N-(p-tolyl)aniline (1122400-34-3) + tributyl(thien-2-yl)stannane (54663-78-4) → 4-(tert-butyl)-N-(4-(thiophen-2-yl)phenyl)-N-(p-tolyl)aniline (1122400-35-4)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In toluene; at 100 ℃; for 24h; Inert atmosphere;

DOI:10.1039/b813478b

Reference yield:

4-tert-Butylaniline (769-92-6) → 4-(tert-butyl)-N-(4-(thiophen-2-yl)phenyl)-N-(p-tolyl)aniline (1122400-35-4)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium t-butanolate; palladium diacetate; tri-tert-butyl phosphine / toluene / 24 h / Inert atmosphere; Reflux; Darkness

2: 1,10-Phenanthroline; copper(l) iodide; potassium hydroxide / toluene / 24 h / Inert atmosphere; Reflux

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / tetrahydrofuran; water / 24 h / Inert atmosphere; Reflux; Darkness

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1,10-Phenanthroline; tri-tert-butyl phosphine; palladium diacetate; potassium carbonate; potassium hydroxide; sodium t-butanolate; In tetrahydrofuran; water; toluene;

upstream raw materials:

4-bromo-N-(4-(tert-butyl)phenyl)-N-(p-tolyl)aniline

tributyl(thien-2-yl)stannane

thiophene boronic acid

4-tert-Butylaniline