5-(2,6-dimethylbenzylidene)-1'-ethyl-4',5',6'-trimethoxy-5H-spiro-[furan-2,3'-indolin]-2'-one

Base Information

Chemical Name:5-(2,6-dimethylbenzylidene)-1'-ethyl-4',5',6'-trimethoxy-5H-spiro-[furan-2,3'-indolin]-2'-one
CAS No.:1608104-60-4
Molecular Formula:C₂₅H₂₇NO₅
Molecular Weight:421.493
Hs Code.:

Synonyms:5-(2,6-dimethylbenzylidene)-1'-ethyl-4',5',6'-trimethoxy-5H-spiro-[furan-2,3'-indolin]-2'-one

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Chemical Property of 5-(2,6-dimethylbenzylidene)-1'-ethyl-4',5',6'-trimethoxy-5H-spiro-[furan-2,3'-indolin]-2'-one

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Technology Process of 5-(2,6-dimethylbenzylidene)-1'-ethyl-4',5',6'-trimethoxy-5H-spiro-[furan-2,3'-indolin]-2'-one

There total 4 articles about 5-(2,6-dimethylbenzylidene)-1'-ethyl-4',5',6'-trimethoxy-5H-spiro-[furan-2,3'-indolin]-2'-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1608112-43-1
5-((2,6-dimethylphenyl)(hydroxy)methyl)-N-ethyl-N-(3,4,5-trimethoxyphenyl)furan-2-carboxamide

: 1608104-60-4
5-(2,6-dimethylbenzylidene)-1'-ethyl-4',5',6'-trimethoxy-5H-spiro-[furan-2,3'-indolin]-2'-one

Guidance literature:: With copper(ll) sulfate pentahydrate; acetic acid; In toluene; at 100 ℃; Inert atmosphere;
DOI:10.1002/ejoc.201301238

Reference yield:

: 1608112-70-4
5-(2,6-dimethylbenzoyl)-N-ethyl-N-(3,4,5-trimethoxyphenyl)furan-2-carboxamide

: 1608104-60-4
5-(2,6-dimethylbenzylidene)-1'-ethyl-4',5',6'-trimethoxy-5H-spiro-[furan-2,3'-indolin]-2'-one

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tetrahydroborate / methanol / 1 h / 20 °C / Inert atmosphere

2: copper(ll) sulfate pentahydrate; acetic acid / toluene / 100 °C / Inert atmosphere

With sodium tetrahydroborate; copper(ll) sulfate pentahydrate; acetic acid; In methanol; toluene; 2: |Friedel-Crafts Alkylation;
DOI:10.1002/ejoc.201301238

Reference yield:

: 1608112-69-1
C₁₄H₁₂O₄

: 1608104-60-4
5-(2,6-dimethylbenzylidene)-1'-ethyl-4',5',6'-trimethoxy-5H-spiro-[furan-2,3'-indolin]-2'-one

Guidance literature:: Multi-step reaction with 4 steps

1: thionyl chloride / 3 h / Reflux; Inert atmosphere

2: triethylamine / Inert atmosphere

3: sodium tetrahydroborate / methanol / 1 h / 20 °C / Inert atmosphere

4: copper(ll) sulfate pentahydrate; acetic acid / toluene / 100 °C / Inert atmosphere

With sodium tetrahydroborate; thionyl chloride; copper(ll) sulfate pentahydrate; acetic acid; triethylamine; In methanol; toluene; 4: |Friedel-Crafts Alkylation;
DOI:10.1002/ejoc.201301238