(S)-2-phenylpropan-2-yl 2-((diphenylmethylene)amino)-3-phenylpropanoate

Base Information

• Chemical Name: (S)-2-phenylpropan-2-yl 2-((diphenylmethylene)amino)-3-phenylpropanoate
• CAS No.: 1351184-95-6
• Molecular Formula: C₃₁H₂₉NO₂
• Molecular Weight: 447.577
• Mol file: 1351184-95-6.mol

Synonyms:(S)-2-phenylpropan-2-yl 2-((diphenylmethylene)amino)-3-phenylpropanoate

Chemical Property of (S)-2-phenylpropan-2-yl 2-((diphenylmethylene)amino)-3-phenylpropanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-phenylpropan-2-yl 2-((diphenylmethylene)amino)-3-phenylpropanoate

There total 10 articles about (S)-2-phenylpropan-2-yl 2-((diphenylmethylene)amino)-3-phenylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

2-phenylpropan-2-yl-2-((diphenylmethylene)amino)acetate (1351184-94-5) + benzyl bromide (100-39-0) → (S)-2-phenylpropan-2-yl 2-((diphenylmethylene)amino)-3-phenylpropanoate (1351184-95-6)

Guidance literature:

2-phenylpropan-2-yl-2-((diphenylmethylene)amino)acetate; benzyl bromide; With Br^(1-)*C₃₇H₃₇N₂O⁽¹⁺⁾; In chloroform; toluene; for 0.05h; Cooling;

With cesiumhydroxide monohydrate; In chloroform; toluene; optical yield given as %ee; enantioselective reaction; Cooling;

DOI:10.1021/ol202939g

Reference yield:

2-phenylpropan-2-yl-2-((diphenylmethylene)amino)acetate (1351184-94-5) + benzyl bromide (100-39-0) → (R)-2-phenylpropan-2-yl 2-((diphenylmethylene)amino)-3-phenylpropanoate + (S)-2-phenylpropan-2-yl 2-((diphenylmethylene)amino)-3-phenylpropanoate (1351184-95-6)

Guidance literature:

2-phenylpropan-2-yl-2-((diphenylmethylene)amino)acetate; benzyl bromide; With Br^(1-)*C₃₇H₃₇N₂O⁽¹⁺⁾; In chloroform;

With cesiumhydroxide monohydrate; In chloroform; optical yield given as %ee; enantioselective reaction;

DOI:10.1021/ol202939g

Reference yield:

bromoacetic acid 1-methyl-1-phenylethyl ester → (S)-2-phenylpropan-2-yl 2-((diphenylmethylene)amino)-3-phenylpropanoate (1351184-95-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 24 h / Inert atmosphere

2.1: Br^(1-)*C₃₇H₃₇N₂O⁽¹⁺⁾ / chloroform; toluene / 0.05 h / Cooling

2.2: Cooling

With Br^(1-)*C₃₇H₃₇N₂O⁽¹⁺⁾; N-ethyl-N,N-diisopropylamine; In chloroform; toluene; acetonitrile;

DOI:10.1021/ol202939g

upstream raw materials:

Benzophenone imine

2-phenylpropan-2-yl-2-((diphenylmethylene)amino)acetate

benzyl bromide

1-methyl-1-phenylethyl alcohol