dimethyl 2,3-dihydro-5-<3-(4-aminophenyl)propyl>-1H-pyrrolizine-6,7-dicarboxylate

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Chemical Name:dimethyl 2,3-dihydro-5-<3-(4-aminophenyl)propyl>-1H-pyrrolizine-6,7-dicarboxylate
CAS No.:218629-17-5
Molecular Formula:C₂₀H₂₄N₂O₄
Molecular Weight:356.422
Hs Code.:

Synonyms:dimethyl 2,3-dihydro-5-<3-(4-aminophenyl)propyl>-1H-pyrrolizine-6,7-dicarboxylate

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Chemical Property of dimethyl 2,3-dihydro-5-<3-(4-aminophenyl)propyl>-1H-pyrrolizine-6,7-dicarboxylate

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Technology Process of dimethyl 2,3-dihydro-5-<3-(4-aminophenyl)propyl>-1H-pyrrolizine-6,7-dicarboxylate

There total 4 articles about dimethyl 2,3-dihydro-5-<3-(4-aminophenyl)propyl>-1H-pyrrolizine-6,7-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 218629-16-4
dimethyl 2,3-dihydro-5-<3-(4-nitrophenyl)propyl>-1H-pyrrolizine-6,7-dicarboxylate

: 218629-17-5
dimethyl 2,3-dihydro-5-<3-(4-aminophenyl)propyl>-1H-pyrrolizine-6,7-dicarboxylate

Guidance literature:: With hydrogen; platinum on activated charcoal; In tetrahydrofuran; methanol; at 20 ℃; for 2h; under 3102.89 Torr;
DOI:10.1021/jm9803119

Reference yield:

: 5600-63-5
4-(4-nitrophenyl)butanoyl chloride

: 218629-17-5
dimethyl 2,3-dihydro-5-<3-(4-aminophenyl)propyl>-1H-pyrrolizine-6,7-dicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: aq. NaOH / diethyl ether / 2 h / 5 - 20 °C

2: Ac₂O / 2 h / 130 - 140 °C

3: 95 percent / H₂ / Pt/C / methanol; tetrahydrofuran / 2 h / 20 °C / 3102.89 Torr

With sodium hydroxide; hydrogen; acetic anhydride; platinum on activated charcoal; In tetrahydrofuran; methanol; diethyl ether;
DOI:10.1021/jm9803119

Reference yield:

: 762-42-5
dimethyl acetylenedicarboxylate

: 218629-17-5
dimethyl 2,3-dihydro-5-<3-(4-aminophenyl)propyl>-1H-pyrrolizine-6,7-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: Ac₂O / 2 h / 130 - 140 °C

2: 95 percent / H₂ / Pt/C / methanol; tetrahydrofuran / 2 h / 20 °C / 3102.89 Torr

With hydrogen; acetic anhydride; platinum on activated charcoal; In tetrahydrofuran; methanol;
DOI:10.1021/jm9803119