Technology Process of C25H23F4NO3
There total 13 articles about C25H23F4NO3 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2,4-difluoro-3-[[2-fluoro-5-(3-fluorophenyl)phenyl]methylamino]-5-methylphenol;
With
caesium carbonate;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 0.5h;
isopropyl 2-bromoacetate;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 1h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: tetrahydrofuran / 2 h / 0 - 20 °C
2.1: borane-THF / tetrahydrofuran / 2 h / 60 °C / Inert atmosphere
3.1: caesium carbonate / N,N-dimethyl-formamide / 0.5 h / 20 °C
3.2: 1 h / 20 °C
With
borane-THF; caesium carbonate;
In
tetrahydrofuran; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: dihydrogen peroxide; water; sodium hydroxide / tetrahydrofuran / 4 h / 20 °C
2.1: 1H-imidazole / N,N-dimethyl-formamide / 0 - 20 °C
3.1: n-butyllithium / tetrahydrofuran; hexane / 2 h / -60 °C / Inert atmosphere
3.2: 1 h / -60 - 20 °C
4.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h / 0 - 20 °C
4.2: 0 - 70 °C
5.1: potassium hydroxide; water / 1,4-dioxane / Reflux
6.1: tetrahydrofuran / 2 h / 0 - 20 °C
7.1: borane-THF / tetrahydrofuran / 2 h / 60 °C / Inert atmosphere
8.1: caesium carbonate / N,N-dimethyl-formamide / 0.5 h / 20 °C
8.2: 1 h / 20 °C
With
1H-imidazole; n-butyllithium; borane-THF; oxalyl dichloride; water; dihydrogen peroxide; caesium carbonate; N,N-dimethyl-formamide; potassium hydroxide; sodium hydroxide;
In
tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane; N,N-dimethyl-formamide;
