2-(4-(2-(3-(3-(2-methylbenzo[d]thiazol-6-ylamino)-3-oxopropyl)ureido)ethyl)phenoxy)malonic acid

Base Information

Chemical Name:2-(4-(2-(3-(3-(2-methylbenzo[d]thiazol-6-ylamino)-3-oxopropyl)ureido)ethyl)phenoxy)malonic acid
CAS No.:1370290-31-5
Molecular Formula:C₂₃H₂₄N₄O₇S
Molecular Weight:500.532
Hs Code.:

Synonyms:2-(4-(2-(3-(3-(2-methylbenzo[d]thiazol-6-ylamino)-3-oxopropyl)ureido)ethyl)phenoxy)malonic acid

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Chemical Property of 2-(4-(2-(3-(3-(2-methylbenzo[d]thiazol-6-ylamino)-3-oxopropyl)ureido)ethyl)phenoxy)malonic acid

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Technology Process of 2-(4-(2-(3-(3-(2-methylbenzo[d]thiazol-6-ylamino)-3-oxopropyl)ureido)ethyl)phenoxy)malonic acid

There total 7 articles about 2-(4-(2-(3-(3-(2-methylbenzo[d]thiazol-6-ylamino)-3-oxopropyl)ureido)ethyl)phenoxy)malonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1370290-48-4
dimethyl 2-(4-(2-(3-(3-(2-methylbenzo[d]thiazol-6-ylamino)-3-oxopropyl)ureido)ethyl)phenoxy)malonate

: 1370290-31-5
2-(4-(2-(3-(3-(2-methylbenzo[d]thiazol-6-ylamino)-3-oxopropyl)ureido)ethyl)phenoxy)malonic acid

Guidance literature:: With water; sodium hydroxide; In tetrahydrofuran; at 20 ℃; for 0.333333h;
DOI:10.1021/jm201734r

Reference yield:

: 2941-62-0
6-amino-2-methylbenzothiazole

: 1370290-31-5
2-(4-(2-(3-(3-(2-methylbenzo[d]thiazol-6-ylamino)-3-oxopropyl)ureido)ethyl)phenoxy)malonic acid

Guidance literature:: Multi-step reaction with 5 steps

1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 16 h / 22 °C

2: trifluoroacetic acid / dichloromethane / 18 h / 22 °C

3: 1-methyl-pyrrolidin-2-one / 40 h / 22 - 70 °C

4: potassium carbonate / N,N-dimethyl-formamide / 22 °C

5: water; sodium hydroxide / tetrahydrofuran / 0.33 h / 20 °C

With water; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm201734r

Reference yield:

: 51-67-2
tyrosamine

: 1370290-31-5
2-(4-(2-(3-(3-(2-methylbenzo[d]thiazol-6-ylamino)-3-oxopropyl)ureido)ethyl)phenoxy)malonic acid

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydrogencarbonate / 1,4-dioxane; water / 4 h / 20 °C / Inert atmosphere

2: 1-methyl-pyrrolidin-2-one / 40 h / 22 - 70 °C

3: potassium carbonate / N,N-dimethyl-formamide / 22 °C

4: water; sodium hydroxide / tetrahydrofuran / 0.33 h / 20 °C

With water; sodium hydrogencarbonate; potassium carbonate; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; water; N,N-dimethyl-formamide;
DOI:10.1021/jm201734r