dimethyl 2-(4-(2-(3-(3-(2-methylbenzo[d]thiazol-6-ylamino)-3-oxopropyl)ureido)ethyl)phenoxy)malonate

Base Information

Chemical Name:dimethyl 2-(4-(2-(3-(3-(2-methylbenzo[d]thiazol-6-ylamino)-3-oxopropyl)ureido)ethyl)phenoxy)malonate
CAS No.:1370290-48-4
Molecular Formula:C₂₅H₂₈N₄O₇S
Molecular Weight:528.586
Hs Code.:

Synonyms:dimethyl 2-(4-(2-(3-(3-(2-methylbenzo[d]thiazol-6-ylamino)-3-oxopropyl)ureido)ethyl)phenoxy)malonate

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Chemical Property of dimethyl 2-(4-(2-(3-(3-(2-methylbenzo[d]thiazol-6-ylamino)-3-oxopropyl)ureido)ethyl)phenoxy)malonate

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Technology Process of dimethyl 2-(4-(2-(3-(3-(2-methylbenzo[d]thiazol-6-ylamino)-3-oxopropyl)ureido)ethyl)phenoxy)malonate

There total 6 articles about dimethyl 2-(4-(2-(3-(3-(2-methylbenzo[d]thiazol-6-ylamino)-3-oxopropyl)ureido)ethyl)phenoxy)malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

: 28868-76-0
2-chlorodimethylmalonate

: 1370290-47-3
3-(3-(4-hydroxyphenethyl)ureido)-N-(2-methylbenzo[d]thiazol-6-yl)propanamide

: 1370290-48-4
dimethyl 2-(4-(2-(3-(3-(2-methylbenzo[d]thiazol-6-ylamino)-3-oxopropyl)ureido)ethyl)phenoxy)malonate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 22 ℃;
DOI:10.1021/jm201734r

Reference yield:

: 2941-62-0
6-amino-2-methylbenzothiazole

: 1370290-48-4
dimethyl 2-(4-(2-(3-(3-(2-methylbenzo[d]thiazol-6-ylamino)-3-oxopropyl)ureido)ethyl)phenoxy)malonate

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 16 h / 22 °C

2: trifluoroacetic acid / dichloromethane / 18 h / 22 °C

3: 1-methyl-pyrrolidin-2-one / 40 h / 22 - 70 °C

4: potassium carbonate / N,N-dimethyl-formamide / 22 °C

With potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; In 1-methyl-pyrrolidin-2-one; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm201734r

Reference yield:

: 51-67-2
tyrosamine

: 1370290-48-4
dimethyl 2-(4-(2-(3-(3-(2-methylbenzo[d]thiazol-6-ylamino)-3-oxopropyl)ureido)ethyl)phenoxy)malonate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydrogencarbonate / 1,4-dioxane; water / 4 h / 20 °C / Inert atmosphere

2: 1-methyl-pyrrolidin-2-one / 40 h / 22 - 70 °C

3: potassium carbonate / N,N-dimethyl-formamide / 22 °C

With sodium hydrogencarbonate; potassium carbonate; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; water; N,N-dimethyl-formamide;
DOI:10.1021/jm201734r