Pyrrolidine, 1-acetyl-2-(methoxymethyl)-, (2S)- (9CI)

Base Information

• Chemical Name: Pyrrolidine, 1-acetyl-2-(methoxymethyl)-, (2S)- (9CI)
• CAS No.: 81390-99-0
• Molecular Formula: C8H15 N O2
• Molecular Weight: 157.213
• Mol file: 81390-99-0.mol

Synonyms:Pyrrolidine,1-acetyl-2-(methoxymethyl)-, (S)-; (2S)-1-Acetyl-2-(methoxymethyl)pyrrolidine

Chemical Property of Pyrrolidine, 1-acetyl-2-(methoxymethyl)-, (2S)- (9CI)

Chemical Property:

• PSA: 29.54000
• LogP: 0.58160

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Pyrrolidine, 1-acetyl-2-(methoxymethyl)-, (2S)- (9CI)

There total 2 articles about Pyrrolidine, 1-acetyl-2-(methoxymethyl)-, (2S)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

(2S,3'RS)-1-(2-aza-1-methyl-3-(tri-n-butylstannyl)-1-butenyl)-2-(methoxymethyl)pyrrolidine + isopropenylbenzene (98-83-9,6144-04-3,25014-31-7,42612-14-6) → 1-acetyl-2-(methoxymethyl)pyrrolidine (81390-99-0) + (2RS,3SR)-2,3,5,-trimethyl-3-phenyl-3,4-dihyro-2H-pyrrole

Guidance literature:

With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 2h;

DOI:10.1016/S0040-4039(01)01539-8

Reference yield:

(2S)-2-(methoxymethyl)-1-pyrrolidine (63126-47-6) + acetyl chloride (75-36-5) → 1-acetyl-2-(methoxymethyl)pyrrolidine (81390-99-0)

Guidance literature:

DOI:10.1021/ja00374a036

upstream raw materials:

(2S)-2-(methoxymethyl)-1-pyrrolidine

acetyl chloride

isopropenylbenzene