N-[3-(3-hydroxypyrrolidin-1-yl)-5-(trifluoromethyl)phenyl]-N-methylmethanesulfonamide

Base Information

Chemical Name:N-[3-(3-hydroxypyrrolidin-1-yl)-5-(trifluoromethyl)phenyl]-N-methylmethanesulfonamide
CAS No.:1198181-35-9
Molecular Formula:C₁₃H₁₇F₃N₂O₃S
Molecular Weight:338.351
Hs Code.:

Synonyms:N-[3-(3-hydroxypyrrolidin-1-yl)-5-(trifluoromethyl)phenyl]-N-methylmethanesulfonamide

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Chemical Property of N-[3-(3-hydroxypyrrolidin-1-yl)-5-(trifluoromethyl)phenyl]-N-methylmethanesulfonamide

Chemical Property:

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Technology Process of N-[3-(3-hydroxypyrrolidin-1-yl)-5-(trifluoromethyl)phenyl]-N-methylmethanesulfonamide

There total 3 articles about N-[3-(3-hydroxypyrrolidin-1-yl)-5-(trifluoromethyl)phenyl]-N-methylmethanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 40499-83-0
pyrrolidin-3-ol

: 1198181-34-8
N-[3-bromo-5-(trifluoromethyl)phenyl]-N-methylmethanesulfonamide

: 1198181-35-9
N-[3-(3-hydroxypyrrolidin-1-yl)-5-(trifluoromethyl)phenyl]-N-methylmethanesulfonamide

Guidance literature:: With caesium carbonate; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In toluene; at 85 ℃; for 16h; Inert atmosphere;

Reference yield:

: 54962-75-3
[3-bromo-5-(trifluoromethyl)phenyl]amine

: 1198181-35-9
N-[3-(3-hydroxypyrrolidin-1-yl)-5-(trifluoromethyl)phenyl]-N-methylmethanesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine / 16 h / 0 - 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 0 - 20 °C

2.2: 16 h / 20 °C

3.1: caesium carbonate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 16 h / 85 °C / Inert atmosphere

With pyridine; sodium hydride; caesium carbonate; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In N,N-dimethyl-formamide; toluene; mineral oil;

Reference yield:

: 871794-92-2
N-(4-bromo-2-(trifluoromethyl^')phenyl)methanesulfonamide

: 1198181-35-9
N-[3-(3-hydroxypyrrolidin-1-yl)-5-(trifluoromethyl)phenyl]-N-methylmethanesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 0 - 20 °C

1.2: 16 h / 20 °C

2.1: caesium carbonate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 16 h / 85 °C / Inert atmosphere

With sodium hydride; caesium carbonate; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In N,N-dimethyl-formamide; toluene; mineral oil;