5-[(7S,9R)-9-((E)-4-Benzyloxy-but-1-enyl)-1,4-dioxa-8-aza-spiro[4.5]dec-7-yl]-2-methoxy-phenol

Base Information

Chemical Name:5-[(7S,9R)-9-((E)-4-Benzyloxy-but-1-enyl)-1,4-dioxa-8-aza-spiro[4.5]dec-7-yl]-2-methoxy-phenol
CAS No.:851755-94-7
Molecular Formula:C₂₅H₃₁NO₅
Molecular Weight:425.525
Hs Code.:

Synonyms:5-[(7S,9R)-9-((E)-4-Benzyloxy-but-1-enyl)-1,4-dioxa-8-aza-spiro[4.5]dec-7-yl]-2-methoxy-phenol

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Chemical Property of 5-[(7S,9R)-9-((E)-4-Benzyloxy-but-1-enyl)-1,4-dioxa-8-aza-spiro[4.5]dec-7-yl]-2-methoxy-phenol

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Technology Process of 5-[(7S,9R)-9-((E)-4-Benzyloxy-but-1-enyl)-1,4-dioxa-8-aza-spiro[4.5]dec-7-yl]-2-methoxy-phenol

There total 9 articles about 5-[(7S,9R)-9-((E)-4-Benzyloxy-but-1-enyl)-1,4-dioxa-8-aza-spiro[4.5]dec-7-yl]-2-methoxy-phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 851755-93-6
[(S)-1-(3-Benzyloxy-4-methoxy-phenyl)-2-(2-methyl-[1,3]dioxolan-2-yl)-ethyl]-[(E)-5-benzyloxy-pent-2-en-(E)-ylidene]-amine

: 851755-94-7
5-[(7S,9R)-9-((E)-4-Benzyloxy-but-1-enyl)-1,4-dioxa-8-aza-spiro[4.5]dec-7-yl]-2-methoxy-phenol

Guidance literature:: With titanium tetrachloride; In dichloromethane; at 0 ℃;
DOI:10.1016/j.tetlet.2005.02.110

Reference yield:

: 851755-89-0
(S)-1-(3-Benzyloxy-4-methoxy-phenyl)-but-3-enylamine

: 851755-94-7
5-[(7S,9R)-9-((E)-4-Benzyloxy-but-1-enyl)-1,4-dioxa-8-aza-spiro[4.5]dec-7-yl]-2-methoxy-phenol

Guidance literature:: Multi-step reaction with 6 steps

1: 87 percent / toluene / Heating

2: 86 percent / O₂ / PdCl₂; CuCl₂ / H₂O; dimethylformamide / 85 °C

3: TsOH / benzene / Heating

4: (NH₂)2*H₂O / ethanol / Heating

5: 100 percent / CHCl₃ / 20 °C

6: 88 percent / TiCl₄ / CH₂Cl₂ / 0 °C

With oxygen; titanium tetrachloride; toluene-4-sulfonic acid; hydrazine hydrate; copper dichloride; palladium dichloride; In ethanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide; toluene; benzene; 2: Wacker oxidation / 6: Mannich-type cyclization;
DOI:10.1016/j.tetlet.2005.02.110

Reference yield:

: 851755-87-8
3-benzyloxy-4-methoxy-benzaldehyde O-(2-hydroxy-2-naphthalen-2-yl-ethyl)-oxime

: 851755-94-7
5-[(7S,9R)-9-((E)-4-Benzyloxy-but-1-enyl)-1,4-dioxa-8-aza-spiro[4.5]dec-7-yl]-2-methoxy-phenol

Guidance literature:: Multi-step reaction with 8 steps

1: diethyl ether; toluene / 0.33 h / 45 °C

2: 82 percent / Zn; AcOH / tetrahydrofuran; H₂O / 60 °C

3: 87 percent / toluene / Heating

4: 86 percent / O₂ / PdCl₂; CuCl₂ / H₂O; dimethylformamide / 85 °C

5: TsOH / benzene / Heating

6: (NH₂)2*H₂O / ethanol / Heating

7: 100 percent / CHCl₃ / 20 °C

8: 88 percent / TiCl₄ / CH₂Cl₂ / 0 °C

With oxygen; titanium tetrachloride; toluene-4-sulfonic acid; hydrazine hydrate; acetic acid; zinc; copper dichloride; palladium dichloride; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide; toluene; benzene; 4: Wacker oxidation / 8: Mannich-type cyclization;
DOI:10.1016/j.tetlet.2005.02.110