(2-Amino-4-methylphenyl)methanol

Base Information

• Chemical Name: (2-Amino-4-methylphenyl)methanol
• CAS No.: 81335-87-7
• Molecular Formula: C8H11 N O
• Molecular Weight: 137.181
• Hs Code.: 2922199090
• Mol file: 81335-87-7.mol

Synonyms:(2-amino-4-methylphenyl)methanol;81335-87-7;2-amino-4-methylbenzyl alcohol;SCHEMBL2889115;(2-Amino-4-methylphenyl)-methanol;MFCD08275453;AKOS006287442;DS-3926;SB83933;CS-0100669;FT-0641820;O10038;EN300-7055766;Z1198176996

Chemical Property of (2-Amino-4-methylphenyl)methanol

Chemical Property:

• PSA: 46.25000
• LogP: 1.65070
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• XLogP3: 1.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 137.084063974
• Heavy Atom Count: 10
• Complexity: 105

Purity/Quality:

98%min ^*data from raw suppliers

(2-Amino-4-methylphenyl)methanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=C(C=C1)CO)N

Technology Process of (2-Amino-4-methylphenyl)methanol

There total 4 articles about (2-Amino-4-methylphenyl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-methyl-2-(picolinamido)benzyl acetate → (2-amino-4-methylphenyl)methanol (81335-87-7)

Guidance literature:

4-methyl-2-(picolinamido)benzyl acetate; With sodium hydroxide; In ethanol; at 70 ℃; for 8h;

With ammonium chloride; In ethyl acetate;

DOI:10.1039/c3ob42196a

Reference yield: 87.0%

4-methylanthranilic acid (2305-36-4) → (2-amino-4-methylphenyl)methanol (81335-87-7)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; for 2h;

Reference yield: 77.0%

(4-methyl 2-nitro-phenyl)-methanol (22996-24-3) → (2-amino-4-methylphenyl)methanol (81335-87-7)

Guidance literature:

With 5%-palladium/activated carbon; hydrogen; In ethanol; at 20 ℃; for 1h;

DOI:10.1055/s-0036-1588470

upstream raw materials:

4-methylanthranilic acid

(4-methyl 2-nitro-phenyl)-methanol

4-methyl-2-nitrobenzoic acid

Downstream raw materials:

2-amino-4-methylbenzaldehyde

2-(4-bromophenyl)-7-methylquinoline

(2-iodo-4-methylphenyl)methanol

2-iodo-4-methylbenzaldehyde

Refernces

• 1、 Wang, Xinyue,Li, Zefei,Feng, Chang,Zhen, Qi,Guo, Mingzhang,Yao, Yaning,Zou, Xinyu,Wang, Pengfei,Hou, Yunlei,Gong, Ping. "A [4+3] Cycloaddition Reaction of Aza-ortho-quinone Methides with C,N-Cyclic Azomethine Imines for Synthesis of 1,2,4-Triazepines". supporting information. p. 2090 - 2096. Retrieved 2021/09/06.
• 2、 Chen, Yang-Bo,Sun, Zhou,Wang, Ze-Shu,Ye, Long-Wu,Zhang, Hao-Wen,Zhu, Chunyin. "Ynamide Smiles Rearrangement Triggered by Visible-Light-Mediated Regioselective Ketyl-Ynamide Coupling: Rapid Access to Functionalized Indoles and Isoquinolines". supporting information. p. 3636 - 3644. Retrieved 2020/03/06.