22996-24-3

Basic information

• Product Name: 4-METHYL-2-NITROBENZYLALCOHOL
• Synonyms: (4-Methyl-2-nitrophenyl)methanol;2-nitro-4-methylbenzyl alcohol
• CAS NO: 22996-24-3
• Molecular Formula: C₈H₉NO₃
• Molecular Weight: 167.16
• Mol File: 22996-24-3.mol

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-METHYL-2-NITROBENZYLALCOHOL(CAS DataBase Reference)
• NIST Chemistry Reference: 4-METHYL-2-NITROBENZYLALCOHOL(22996-24-3)
• EPA Substance Registry System: 4-METHYL-2-NITROBENZYLALCOHOL(22996-24-3)

Safety Data

• Hazardous Substances Data: 22996-24-3(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
4-Methyl-2-nitrobenzylalcohol is used as a protecting group for alcohols, which is crucial in organic synthesis to prevent unwanted reactions from occurring at the alcohol functional group. This allows chemists to selectively modify other parts of a molecule without affecting the alcohol.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 4-Methyl-2-nitrobenzylalcohol is utilized as a precursor in the synthesis of various medications. Its unique chemical properties make it a valuable component in the development of new drugs with specific therapeutic effects.
Used in Advanced Materials Synthesis:
4-Methyl-2-nitrobenzylalcohol has potential applications in the synthesis of advanced materials, where its chemical structure can contribute to the creation of novel materials with specialized properties for various applications.
Used in Drug Development:
As a building block in drug development, 4-Methyl-2-nitrobenzylalcohol plays a role in the design and synthesis of new drug molecules. Its incorporation into drug candidates can lead to the discovery of innovative treatments for a range of diseases and conditions.
Safety Considerations:
It is important to handle 4-Methyl-2-nitrobenzylalcohol with caution, as it can be hazardous if not properly handled and stored. Adequate safety measures should be taken to minimize risks associated with its use in research and industrial applications.

Upstream product

• 27329-27-7 4-methyl-2-nitrobenzoic acid 
• 20587-29-5 methyl 4-methyl-2-nitrobenzoate 
• 20357-22-6 2-nitro-4-methylbenzaldehyde 

Downstream Products

• 1422192-61-7 1-Boc-3-(5-chloro-2-nitrobenzylidene)piperidine 
• 1422192-73-1 1-Boc-3-(5-chloro-2-nitrobenzylidene)piperidine 
• 503856-38-0 diethyl 4-methyl-2-nitrobenzylphosphonate 
• 59236-38-3 2-amino-4-methylbenzaldehyde 
• 81335-87-7 (2-amino-4-methylphenyl)methanol 
• 503856-32-4 1-(bromomethyl)-4-methyl-2-nitrobenzene 
• 1290617-55-8 tert-butyl N-(diphenylmethylidene)-4-methyl-2-nitro-L-phenylalaninate 
• 20357-22-6 2-nitro-4-methylbenzaldehyde 

Relevant articles and documents

MOLECULES HAVING CERTAIN PESTICIDAL UTILITIES, AND INTERMEDIATES, COMPOSITIONS, AND PROCESSES RELATED THERETO

This disclosure relates to compounds having pesticidal utility against pests in phyla Nematoda, Arthropoda, and/or Mollusca, processes to produce such compounds and intermediates used in such processes, compositions containing such compounds, and processes of using such compounds against such pests. These compounds/molecules may be used, for example, as nematicides, acaricides, insecticides, miticides, and/or molluscicides. This document discloses compounds having the following formula (Formula One and/or Formula One-A).

Compound with dual inhibitory activity TDO, IDOO1 and application of compound for treating neurodegenerative disease (by machine translation)

The present invention provides a compound of formula I, or a pharmaceutically acceptable salt thereof, or a solvate thereof, which can selectively inhibit TDO, IDOO1, which has a significant inhibitory effect on TDO and/or IDOO1. In addition, the prepared compound has a remarkable anti-tumor effect, has a certain treatment effect on's disease and's disease, and has a good application prospect in the field of medicine preparation. (by machine translation)

Intramolecular Pd-catalyzed reductive amination of enolizable sp3-C-H bonds

A palladium-catalyzed reductive cyclization of nitroarenes has been designed to construct sp3-C-NHAr bonds from sp3-C-H bonds by using an enolizable nucleophile to intercept a nitrosoarene intermediate. Exposure of ortho-substituted nitroarenes to 5 mol ?% of Pd(OAc)2 and 10 mol ?% of phenanthroline under 2 atm of CO constructs partially saturated 5-, 6-, or 7-membered N-heterocycles using α-pyridyl carboxylates, malonates, 1,3-dimethylbarbituric acid, 1,3-diones, or difurans as the nucleophile.

Easy Access to Quinolin-2(1 H)-ones via a One-Pot Tandem Oxa-Michael-Aldol Sequence

An efficient strategy for the synthesis of a variety of quinolin-2(1 H)-one derivatives has been developed. The reaction proceeded from cinnamide derivatives via a tandem reaction in the presence of NaOH to afford the corresponding 2- quinolin-2(1 H)-one derivatives in good to excellent yields.

NEW SUBSTITUTED CYANOINDOLINE DERIVATIVES AS NIK INHIBITORS

The present invention relates to pharmaceutical agents of formula (I) useful for therapy and/or prophylaxis in a mammal, and in particular to inhibitors of NF- KB-inducing kinase (NIK - also known as MAP3K14) useful for treating diseases such as cancer, inflammatory disorders, metabolic disorders and autoimmune disorders. The invention is also directed to pharmaceutical compositions comprising such compounds, and to the use of such compounds or pharmaceutical compositions for the prevention or treatment of diseases such as cancer, inflammatory disorders, metabolic disorders including obesity and diabetes, and autoimmune disorders.

Rh2(II)-catalyzed selective aminomethylene migration from styryl azides

Rh2(II)-Carboxylate complexes were discovered to promote the selective migration of aminomethylenes in β,β-disubstituted styryl azides to form 2,3-disubstituted indoles. Mechanistic data are also presented that suggest that the migration occurs stepwise before diffusion of the iminium ion.

Synthesis of quinolinomorphinan derivatives as highly selective δ opioid receptor ligands

We have reported previously the novel δ opioid agonist KNT-127 which showed high affinity and selectivity for the δ receptor. Moreover, the analgesic effect of subcutaneously administered KNT-127 was more potent than that of a prototypical δ agonist (-)-TAN-67 in the acetic acid writhing test. This study of the structure-activity relationship of KNT-127 derivatives focused on the introduction of substituents onto the 5′-, 6′-, 7′- or 8′-position of the quinoline ring and revealed that many derivatives with 5′- or 8′-substituents showed high affinities and selectivities for the δ receptor. Especially, SYK-153 with an 8′-OH group showed the highest affinity and the most balanced and highest selectivity for the δ receptor among the synthesized compounds.

COMPOUNDS WHICH HAVE ACTIVITY AT M1 RECEPTOR AND THEIR USES IN MEDICINE

Compounds of formula (I) or a salt thereof are provided: wherein R4, R5, R6, Q, A, Y and R are as defined in the description. Uses of the compounds as medicaments and in the manufacture of medicaments for treating psychotic disorders, cognitive impairments and Alzheimer's Disease are disclosed. The invention further discloses pharmaceutical compositions comprising the compounds.