(7-methyl-1,4-diazepan-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone

Base Information

• Chemical Name: (7-methyl-1,4-diazepan-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone
• CAS No.: 1001401-59-7
• Molecular Formula: C₁₆H₂₁N₅O
• Molecular Weight: 299.376
• Mol file: 1001401-59-7.mol

Synonyms:(7-methyl-1,4-diazepan-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone

Chemical Property of (7-methyl-1,4-diazepan-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (7-methyl-1,4-diazepan-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone

There total 20 articles about (7-methyl-1,4-diazepan-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

benzyl 5-methyl-4-(5-methyl-2-(2H-1,2,3-triazole-2-yl)benzoyl)-1,4-diazepane-1-carboxylate (1352834-54-8) → (7-methyl-1,4-diazepan-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone (1001401-59-7)

Guidance literature:

With 20 wt.% Pd(OH)2 on activated carbon; hydrogen; In methanol; ethyl acetate; at 20 ℃; for 18h; under 760.051 Torr;

DOI:10.1002/anie.201104735

Reference yield: 69.0%

7-methyl-1-(5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoyl)-1,4-diazepan-5-one → (7-methyl-1,4-diazepan-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone (1001401-59-7)

Guidance literature:

With sodium tetrahydroborate; trifluoroacetic acid; In 2-methyltetrahydrofuran; at 45 - 55 ℃; for 16h;

Reference yield:

allyl 5-methyl-4-(5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoyl)-1,4-diazepane-1-carboxylate (1001401-58-6) → (7-methyl-1,4-diazepan-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone (1001401-59-7)

Guidance literature:

With piperidine; sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; at 20 ℃; for 1h;

upstream raw materials:

allyl 5-methyl-4-(5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoyl)-1,4-diazepane-1-carboxylate

2-Amino-5-methylbenzoic acid

2-(2H-1,2,3-triazol-2-yl)-5-methylbenzoic acid

benzyl (2-((tert-butoxycarbonyl)amino)ethyl)(3-oxobutanoyl)carbamate

Downstream raw materials:

(4-(5-chlorobenzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone