benzyl 5-methyl-4-(5-methyl-2-(2H-1,2,3-triazole-2-yl)benzoyl)-1,4-diazepane-1-carboxylate

Base Information

Chemical Name:benzyl 5-methyl-4-(5-methyl-2-(2H-1,2,3-triazole-2-yl)benzoyl)-1,4-diazepane-1-carboxylate
CAS No.:1352834-54-8
Molecular Formula:C₂₄H₂₇N₅O₃
Molecular Weight:433.51
Hs Code.:

Synonyms:benzyl 5-methyl-4-(5-methyl-2-(2H-1,2,3-triazole-2-yl)benzoyl)-1,4-diazepane-1-carboxylate

Suppliers and Price of benzyl 5-methyl-4-(5-methyl-2-(2H-1,2,3-triazole-2-yl)benzoyl)-1,4-diazepane-1-carboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of benzyl 5-methyl-4-(5-methyl-2-(2H-1,2,3-triazole-2-yl)benzoyl)-1,4-diazepane-1-carboxylate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of benzyl 5-methyl-4-(5-methyl-2-(2H-1,2,3-triazole-2-yl)benzoyl)-1,4-diazepane-1-carboxylate

There total 5 articles about benzyl 5-methyl-4-(5-methyl-2-(2H-1,2,3-triazole-2-yl)benzoyl)-1,4-diazepane-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 956317-36-5
2-(2H-1,2,3-triazol-2-yl)-5-methylbenzoic acid

: 1352834-53-7
(rac)-benzyl 5-methyl-1,4-diazepane-1-carboxylate hydrochloride

: 1352834-54-8
benzyl 5-methyl-4-(5-methyl-2-(2H-1,2,3-triazole-2-yl)benzoyl)-1,4-diazepane-1-carboxylate

Guidance literature:: With 4-methyl-morpholine; 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 14h;
DOI:10.1002/anie.201104735

Reference yield:

: 2941-78-8
2-Amino-5-methylbenzoic acid

: 1352834-54-8
benzyl 5-methyl-4-(5-methyl-2-(2H-1,2,3-triazole-2-yl)benzoyl)-1,4-diazepane-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride; sodium nitrite / water / 2.5 h / 0 °C

1.2: 14 h / 80 °C / Cooling with ice

2.1: copper(l) iodide; potassium carbonate; N,N-dimethylethylenediamine / N,N-dimethyl-formamide / 14 h / 120 °C

3.1: 4-methyl-morpholine; 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 14 h / 20 °C

With 4-methyl-morpholine; hydrogenchloride; copper(l) iodide; 1-hydroxy-7-aza-benzotriazole; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N,N-dimethylethylenediamine; sodium nitrite; In water; N,N-dimethyl-formamide;
DOI:10.1002/anie.201104735

Reference yield:

: 1030377-24-2
1-benzyl 4-tert-butyl 5-methyl-1,4-diazepane-1,4-dicarboxylate

: 1352834-54-8
benzyl 5-methyl-4-(5-methyl-2-(2H-1,2,3-triazole-2-yl)benzoyl)-1,4-diazepane-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / methanol / 14 h / 20 °C

2: 4-methyl-morpholine; 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 14 h / 20 °C

With 4-methyl-morpholine; hydrogenchloride; 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; N,N-dimethyl-formamide;
DOI:10.1002/anie.201104735