2-Acetylamino-2-{3-[4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-propyl}-malonic acid diethyl ester

Base Information

Chemical Name:2-Acetylamino-2-{3-[4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-propyl}-malonic acid diethyl ester
CAS No.:204329-84-0
Molecular Formula:C₂₀H₂₄F₃N₃O₅
Molecular Weight:443.423
Hs Code.:

Synonyms:2-Acetylamino-2-{3-[4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-propyl}-malonic acid diethyl ester

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Chemical Property of 2-Acetylamino-2-{3-[4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-propyl}-malonic acid diethyl ester

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Technology Process of 2-Acetylamino-2-{3-[4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-propyl}-malonic acid diethyl ester

There total 11 articles about 2-Acetylamino-2-{3-[4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-propyl}-malonic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1068-90-2
2-acetylaminomalonic acid diethyl ester

: 271252-21-2
3-[4-(3-Bromo-propyl)-phenyl]-3-trifluoromethyl-3H-diazirine

: 204329-84-0
2-Acetylamino-2-{3-[4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-propyl}-malonic acid diethyl ester

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide;
DOI:10.1246/cl.1998.203

Reference yield:

: 25574-11-2
3-(4-bromophenyl)propanol

: 204329-84-0
2-Acetylamino-2-{3-[4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-propyl}-malonic acid diethyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: imidazole / dimethylformamide

2: 79 percent / 1.) n-BuLi / diethyl ether / -42 °C / 1.) -42 -> 0 deg C

3: 91 percent / NH₂OH*HCl, Et₃N / ethanol / Heating

4: 98 percent / pyridine / 0 deg C -> room temp.

5: 98 percent / liq. NH₃ / diethyl ether / -78 -> -33 deg C -> room temp.

6: 1.) t-BuOCl; 2.) Et₃N / 1.) Et₂O, -50 deg C; 2.) Et₂O, -50 deg C -> room temp.

7: CSA / methanol

8: 95 percent / CBr₄, PPh₃ / toluene

9: 75 percent / NaH / dimethylformamide

With pyridine; 1H-imidazole; n-butyllithium; tert-butylhypochlorite; carbon tetrabromide; camphor-10-sulfonic acid; hydroxylamine hydrochloride; ammonia; sodium hydride; triethylamine; triphenylphosphine; In methanol; diethyl ether; ethanol; N,N-dimethyl-formamide; toluene;
DOI:10.1246/cl.1998.203

Reference yield:

: 75567-84-9
methyl 3-(4-bromopehynl)propanoate

: 204329-84-0
2-Acetylamino-2-{3-[4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-propyl}-malonic acid diethyl ester

Guidance literature:: Multi-step reaction with 10 steps

1: 94 percent / LiAlH₄ / diethyl ether / Heating

2: imidazole / dimethylformamide

3: 79 percent / 1.) n-BuLi / diethyl ether / -42 °C / 1.) -42 -> 0 deg C

4: 91 percent / NH₂OH*HCl, Et₃N / ethanol / Heating

5: 98 percent / pyridine / 0 deg C -> room temp.

6: 98 percent / liq. NH₃ / diethyl ether / -78 -> -33 deg C -> room temp.

7: 1.) t-BuOCl; 2.) Et₃N / 1.) Et₂O, -50 deg C; 2.) Et₂O, -50 deg C -> room temp.

8: CSA / methanol

9: 95 percent / CBr₄, PPh₃ / toluene

10: 75 percent / NaH / dimethylformamide

With pyridine; 1H-imidazole; lithium aluminium tetrahydride; n-butyllithium; tert-butylhypochlorite; carbon tetrabromide; camphor-10-sulfonic acid; hydroxylamine hydrochloride; ammonia; sodium hydride; triethylamine; triphenylphosphine; In methanol; diethyl ether; ethanol; N,N-dimethyl-formamide; toluene;
DOI:10.1246/cl.1998.203