Technology Process of 3-[4-(3-Bromo-propyl)-phenyl]-3-trifluoromethyl-3H-diazirine
There total 9 articles about 3-[4-(3-Bromo-propyl)-phenyl]-3-trifluoromethyl-3H-diazirine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
carbon tetrabromide; triphenylphosphine;
In
toluene;
DOI:10.1246/cl.1998.203
- Guidance literature:
-
Multi-step reaction with 8 steps
1: imidazole / dimethylformamide
2: 79 percent / 1.) n-BuLi / diethyl ether / -42 °C / 1.) -42 -> 0 deg C
3: 91 percent / NH2OH*HCl, Et3N / ethanol / Heating
4: 98 percent / pyridine / 0 deg C -> room temp.
5: 98 percent / liq. NH3 / diethyl ether / -78 -> -33 deg C -> room temp.
6: 1.) t-BuOCl; 2.) Et3N / 1.) Et2O, -50 deg C; 2.) Et2O, -50 deg C -> room temp.
7: CSA / methanol
8: 95 percent / CBr4, PPh3 / toluene
With
pyridine; 1H-imidazole; n-butyllithium; tert-butylhypochlorite; carbon tetrabromide; camphor-10-sulfonic acid; hydroxylamine hydrochloride; ammonia; triethylamine; triphenylphosphine;
In
methanol; diethyl ether; ethanol; N,N-dimethyl-formamide; toluene;
DOI:10.1246/cl.1998.203
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 94 percent / LiAlH4 / diethyl ether / Heating
2: imidazole / dimethylformamide
3: 79 percent / 1.) n-BuLi / diethyl ether / -42 °C / 1.) -42 -> 0 deg C
4: 91 percent / NH2OH*HCl, Et3N / ethanol / Heating
5: 98 percent / pyridine / 0 deg C -> room temp.
6: 98 percent / liq. NH3 / diethyl ether / -78 -> -33 deg C -> room temp.
7: 1.) t-BuOCl; 2.) Et3N / 1.) Et2O, -50 deg C; 2.) Et2O, -50 deg C -> room temp.
8: CSA / methanol
9: 95 percent / CBr4, PPh3 / toluene
With
pyridine; 1H-imidazole; lithium aluminium tetrahydride; n-butyllithium; tert-butylhypochlorite; carbon tetrabromide; camphor-10-sulfonic acid; hydroxylamine hydrochloride; ammonia; triethylamine; triphenylphosphine;
In
methanol; diethyl ether; ethanol; N,N-dimethyl-formamide; toluene;
DOI:10.1246/cl.1998.203
