(2-chloro-4-nitro-phenyl)-(3,4,11,11a-tetrahydro-1H,5H-2-oxa-4a,10-diaza-dibenzo[a,d]cyclohepten-10-yl)-methanone

Base Information

• Chemical Name: (2-chloro-4-nitro-phenyl)-(3,4,11,11a-tetrahydro-1H,5H-2-oxa-4a,10-diaza-dibenzo[a,d]cyclohepten-10-yl)-methanone
• CAS No.: 285559-80-0
• Molecular Formula: C₁₉H₁₈ClN₃O₄
• Molecular Weight: 387.823
• Mol file: 285559-80-0.mol

Synonyms:(2-chloro-4-nitro-phenyl)-(3,4,11,11a-tetrahydro-1H,5H-2-oxa-4a,10-diaza-dibenzo[a,d]cyclohepten-10-yl)-methanone

Chemical Property of (2-chloro-4-nitro-phenyl)-(3,4,11,11a-tetrahydro-1H,5H-2-oxa-4a,10-diaza-dibenzo[a,d]cyclohepten-10-yl)-methanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2-chloro-4-nitro-phenyl)-(3,4,11,11a-tetrahydro-1H,5H-2-oxa-4a,10-diaza-dibenzo[a,d]cyclohepten-10-yl)-methanone

There total 1 articles about (2-chloro-4-nitro-phenyl)-(3,4,11,11a-tetrahydro-1H,5H-2-oxa-4a,10-diaza-dibenzo[a,d]cyclohepten-10-yl)-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

2-chloro-4-nitrobenzoyl chloride (7073-36-1) + (S)-(+)-3,4,5,10,11,11a-hexahydro-1H-2-oxa-4a,10-diazadibenzo[a,d]cycloheptene (285559-79-7) → (2-chloro-4-nitro-phenyl)-(3,4,11,11a-tetrahydro-1H,5H-2-oxa-4a,10-diaza-dibenzo[a,d]cyclohepten-10-yl)-methanone (285559-80-0)

Guidance literature:

With triethylamine; In dichloromethane;

DOI:10.1016/j.bmcl.2004.03.083

Reference yield: 97.0%

(2-chloro-4-nitro-phenyl)-(3,4,11,11a-tetrahydro-1H,5H-2-oxa-4a,10-diaza-dibenzo[a,d]cyclohepten-10-yl)-methanone (285559-80-0) → (4-amino-2-chloro-phenyl)-(3,4,11,11a-tetrahydro-1H,5H-2-oxa-4a,10-diaza-dibenzo[a,d]cyclohepten-10-yl)-methanone (285559-81-1)

Guidance literature:

With ammonium chloride; zinc; In methanol;

DOI:10.1016/j.bmcl.2004.03.083

Reference yield:

(2-chloro-4-nitro-phenyl)-(3,4,11,11a-tetrahydro-1H,5H-2-oxa-4a,10-diaza-dibenzo[a,d]cyclohepten-10-yl)-methanone (285559-80-0) → 4-fluoro-biphenyl-2-carboxylic acid [3-chloro-4-(3,4,11,11a-tetrahydro-1H,5H-2-oxa-4a,10-diaza-dibenzo[a,d]cycloheptene-10-carbonyl)-phenyl]-amide

Guidance literature:

Multi-step reaction with 2 steps

1: 97 percent / Zn; NH₄Cl / methanol

2: Et₃N / CH₂Cl₂

With ammonium chloride; triethylamine; zinc; In methanol; dichloromethane;

DOI:10.1016/j.bmcl.2004.03.083

upstream raw materials:

2-chloro-4-nitrobenzoyl chloride

(S)-(+)-3,4,5,10,11,11a-hexahydro-1H-2-oxa-4a,10-diazadibenzo[a,d]cycloheptene

Downstream raw materials:

(4-amino-2-chloro-phenyl)-(3,4,11,11a-tetrahydro-1H,5H-2-oxa-4a,10-diaza-dibenzo[a,d]cyclohepten-10-yl)-methanone