1-benzyloxycarbonylamino-7-tert-butyloxycarbonylaminooctane

Base Information

Chemical Name:1-benzyloxycarbonylamino-7-tert-butyloxycarbonylaminooctane
CAS No.:207980-87-8
Molecular Formula:C₂₁H₃₄N₂O₄
Molecular Weight:378.512
Hs Code.:

Synonyms:1-benzyloxycarbonylamino-7-tert-butyloxycarbonylaminooctane

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Chemical Property of 1-benzyloxycarbonylamino-7-tert-butyloxycarbonylaminooctane

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Technology Process of 1-benzyloxycarbonylamino-7-tert-butyloxycarbonylaminooctane

There total 11 articles about 1-benzyloxycarbonylamino-7-tert-butyloxycarbonylaminooctane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 13139-17-8
N-(Benzyloxycarbonyloxy)succinimide

: 207980-84-5
1-amino-7-tert-butyloxycarbonylaminooctane

: 207980-87-8
1-benzyloxycarbonylamino-7-tert-butyloxycarbonylaminooctane

Guidance literature:: In chloroform; Ambient temperature;
DOI:10.1016/S0968-0896(97)10030-X

Reference yield:

: 62992-46-5
1-(tetrahydropyranyloxy)-4-pentyn

: 207980-87-8
1-benzyloxycarbonylamino-7-tert-butyloxycarbonylaminooctane

Guidance literature:: Multi-step reaction with 10 steps

1: 1.) n-butyllithium, 2.) hexamethylphosphoramide / 1.) THF, hexane, 2 h, 2.) THF, hexane, -50 deg C -> room temperature

2: 92 percent / triethylamine / CH₂Cl₂ / 0.25 h

3: 67 percent / NaN₃ / dimethylsulfoxide

4: 96 percent / hydrogen / PtO₂ / ethanol / 6 h / 2068.6 Torr

5: 94 percent / dimethylformamide / 0.5 h

6: 86 percent / pyridinium-p-toluene sulfonate / aq. ethanol / 5 h / 53 - 58 °C

7: 87 percent / triethylamine / CH₂Cl₂ / 0.25 h

8: 89 percent / NaN₃ / dimethylsulfoxide

9: 98 percent / hydrogen / PtO₂ / ethanol / 6 h / 2068.6 Torr

10: 85 percent / CHCl₃ / Ambient temperature

With N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; sodium azide; hydrogen; pyridinium p-toluenesulfonate; triethylamine; platinum(IV) oxide; In ethanol; dichloromethane; chloroform; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(97)10030-X

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 207980-87-8
1-benzyloxycarbonylamino-7-tert-butyloxycarbonylaminooctane

Guidance literature:: Multi-step reaction with 6 steps

1: 94 percent / dimethylformamide / 0.5 h

2: 86 percent / pyridinium-p-toluene sulfonate / aq. ethanol / 5 h / 53 - 58 °C

3: 87 percent / triethylamine / CH₂Cl₂ / 0.25 h

4: 89 percent / NaN₃ / dimethylsulfoxide

5: 98 percent / hydrogen / PtO₂ / ethanol / 6 h / 2068.6 Torr

6: 85 percent / CHCl₃ / Ambient temperature

With sodium azide; hydrogen; pyridinium p-toluenesulfonate; triethylamine; platinum(IV) oxide; In ethanol; dichloromethane; chloroform; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(97)10030-X