(4S)-4,5-dihydro-2-(2′-(3,5-bis(trifluoromethyl)anilino)phenyl)-4-isopropyloxazole

Base Information

Chemical Name:(4S)-4,5-dihydro-2-(2′-(3,5-bis(trifluoromethyl)anilino)phenyl)-4-isopropyloxazole
CAS No.:1609167-94-3
Molecular Formula:C₂₀H₁₈F₆N₂O
Molecular Weight:416.366
Hs Code.:

Synonyms:(4S)-4,5-dihydro-2-(2′-(3,5-bis(trifluoromethyl)anilino)phenyl)-4-isopropyloxazole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4S)-4,5-dihydro-2-(2′-(3,5-bis(trifluoromethyl)anilino)phenyl)-4-isopropyloxazole

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Technology Process of (4S)-4,5-dihydro-2-(2′-(3,5-bis(trifluoromethyl)anilino)phenyl)-4-isopropyloxazole

There total 3 articles about (4S)-4,5-dihydro-2-(2′-(3,5-bis(trifluoromethyl)anilino)phenyl)-4-isopropyloxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 148836-24-2
(-)-(S)-2-(2-bromo-phenyl)-4-isopropyl-4,5-dihydro-oxazole

: 328-74-5
3,5-Bis-(trifluoromethyl)aniline

: 1609167-94-3
(4S)-4,5-dihydro-2-(2′-(3,5-bis(trifluoromethyl)anilino)phenyl)-4-isopropyloxazole

Guidance literature:: With palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; In toluene; at 100 ℃; for 48h; Schlenk technique; Inert atmosphere;
DOI:10.1021/om401226j

Reference yield:

: 6630-33-7
ortho-bromobenzaldehyde

: 1609167-94-3
(4S)-4,5-dihydro-2-(2′-(3,5-bis(trifluoromethyl)anilino)phenyl)-4-isopropyloxazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: toluene / 24 h / Inert atmosphere

1.2: 5 h / 20 °C / Inert atmosphere

2.1: palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate / toluene / 48 h / 100 °C / Schlenk technique; Inert atmosphere

With palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; In toluene;
DOI:10.1021/om401226j

Reference yield:

: 2026-48-4,473-75-6
(S)-valinol

: 1609167-94-3
(4S)-4,5-dihydro-2-(2′-(3,5-bis(trifluoromethyl)anilino)phenyl)-4-isopropyloxazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: toluene / 24 h / Inert atmosphere

1.2: 5 h / 20 °C / Inert atmosphere

2.1: palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate / toluene / 48 h / 100 °C / Schlenk technique; Inert atmosphere

With palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; In toluene;
DOI:10.1021/om401226j