(5-bromo-2-hydroxy-phenyl)-[1-(4-chloro-phenyl)-1H-pyrazol-4-yl]-methanone

Base Information

• Chemical Name: (5-bromo-2-hydroxy-phenyl)-[1-(4-chloro-phenyl)-1H-pyrazol-4-yl]-methanone
• CAS No.: 916515-42-9
• Molecular Formula: C₁₆H₁₀BrClN₂O₂
• Molecular Weight: 377.625

Synonyms:(5-bromo-2-hydroxy-phenyl)-[1-(4-chloro-phenyl)-1H-pyrazol-4-yl]-methanone

Chemical Property of (5-bromo-2-hydroxy-phenyl)-[1-(4-chloro-phenyl)-1H-pyrazol-4-yl]-methanone

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Technology Process of (5-bromo-2-hydroxy-phenyl)-[1-(4-chloro-phenyl)-1H-pyrazol-4-yl]-methanone

There total 1 articles about (5-bromo-2-hydroxy-phenyl)-[1-(4-chloro-phenyl)-1H-pyrazol-4-yl]-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-bromo-4-oxo-4H-chromene-3-carbaldehyde (52817-12-6) + N-4-chlorophenylhydrazine (1073-69-4) → (5-bromo-2-hydroxy-phenyl)-[1-(4-chloro-phenyl)-1H-pyrazol-4-yl]-methanone (916515-42-9)

Guidance literature:

With potassium hydroxide; In ethanol; at 120 ℃; for 0.116667h; microwave irradiation;

DOI:10.1021/jm060657g

Reference yield:

(5-bromo-2-hydroxy-phenyl)-[1-(4-chloro-phenyl)-1H-pyrazol-4-yl]-methanone (916515-42-9) + ethyl bromoacetate (105-36-2) → {4-bromo-2-[1-(4-chloro-phenyl)-1H-pyrazole-4-carbonyl]-phenoxy}-acetic acid ethyl ester (916515-54-3)

Guidance literature:

With potassium carbonate; In acetone; at 20 ℃; for 12h;

DOI:10.1021/jm060657g

Reference yield:

(5-bromo-2-hydroxy-phenyl)-[1-(4-chloro-phenyl)-1H-pyrazol-4-yl]-methanone (916515-42-9) → {4-bromo-2-[1-(4-chloro-phenyl)-1H-pyrazole-4-carbonyl]-phenoxy}-acetic acid

Guidance literature:

Multi-step reaction with 2 steps

1: K₂CO₃ / acetone / 12 h / 20 °C

2: LiOH*H₂O / tetrahydrofuran; H₂O / 20 °C

With lithium hydroxide; potassium carbonate; In tetrahydrofuran; water; acetone;

DOI:10.1021/jm060657g

upstream raw materials:

6-bromo-4-oxo-4H-chromene-3-carbaldehyde

N-4-chlorophenylhydrazine

Downstream raw materials:

{4-bromo-2-[1-(4-chloro-phenyl)-1H-pyrazole-4-carbonyl]-phenoxy}-acetic acid ethyl ester

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