Technology Process of 6-[(2S,3R,4S,5R,8S)-3,9-Bis-(tert-butyl-dimethyl-silanyloxy)-5-hydroxy-2,4,8-trimethyl-nonyl]-2,4-dimethoxy-3-methyl-phenol
There total 13 articles about 6-[(2S,3R,4S,5R,8S)-3,9-Bis-(tert-butyl-dimethyl-silanyloxy)-5-hydroxy-2,4,8-trimethyl-nonyl]-2,4-dimethoxy-3-methyl-phenol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
pyridinium p-toluenesulfonate;
In
propan-1-ol;
at 20 ℃;
for 1h;
Inert atmosphere;
DOI:10.1002/anie.201400305
- Guidance literature:
-
With
pyridinium p-toluenesulfonate;
In
propan-1-ol;
at 20 ℃;
DOI:10.1039/b402391a
- Guidance literature:
-
Multi-step reaction with 12 steps
1.1: NaH / tetrahydrofuran / 0 °C
2.1: 82 percent / NaI; BF3*OEt2 / acetonitrile / 20 °C
3.1: NaHMDS / tetrahydrofuran / -78 °C
4.1: LiAlH4 / tetrahydrofuran / -78 - 0 °C
5.1: Dess-Martin periodinane / CH2Cl2 / 20 °C
6.1: (R,R)-diisopropyl tartrate; 4 Angstroem molecular sieves / toluene / -78 °C
7.1: 100 percent / 2,6-lutidine / CH2Cl2 / 0 °C
8.1: aq. OsO4; NaIO4 / tetrahydrofuran / 20 °C
9.1: n-BuLi / tetrahydrofuran / -78 °C
9.2: tetrahydrofuran
10.1: 100 percent / DMAP; pyridine / 20 °C
11.1: m-CPBA / CH2Cl2 / 20 °C
12.1: DIBAL-H / CH2Cl2 / -78 °C
With
pyridine; 2,6-dimethylpyridine; dmap; sodium periodate; osmium(VIII) oxide; lithium aluminium tetrahydride; n-butyllithium; L-(+)-diisopropyl tartrate; 4 A molecular sieve; boron trifluoride diethyl etherate; sodium hexamethyldisilazane; sodium hydride; diisobutylaluminium hydride; Dess-Martin periodane; 3-chloro-benzenecarboperoxoic acid; sodium iodide;
In
tetrahydrofuran; dichloromethane; toluene; acetonitrile;
DOI:10.1039/b402391a
