35052-27-8

Basic information

• Product Name: (3,5-dimethoxy-4-methylphenyl)methanol
• Synonyms: (3,5-dimethoxy-4-methylphenyl)methanol
• CAS NO: 35052-27-8
• Molecular Formula: C₁₀H₁₄O₃
• Molecular Weight: 182.21636
• Mol File: 35052-27-8.mol
• Article Data: 3

Chemical Properties

• Melting Point: 55-57 °C(Solv: ethanol (64-17-5))
• Boiling Point: 301.9±37.0 °C(Predicted)
• Appearance: /
• Density: 1.087±0.06 g/cm3(Predicted)
• Solubility: Dichloromethane
• PKA: 14.25±0.10(Predicted)
• CAS DataBase Reference: (3,5-dimethoxy-4-methylphenyl)methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (3,5-dimethoxy-4-methylphenyl)methanol(35052-27-8)
• EPA Substance Registry System: (3,5-dimethoxy-4-methylphenyl)methanol(35052-27-8)

Safety Data

• Hazardous Substances Data: 35052-27-8(Hazardous Substances Data)

Usage

Uses

3,5-Dimethoxy-4-methylbenzenemethanol is an intermediate used in the synthesis of 8,10-Dihydroxy-cannabinol (D448803), which is a degradation compound of ?9-Tetrahydro Cannabinol (T293200), the principal active constituent of cannabis.

Upstream product

• 61040-81-1 4-methyl-3,5-dimethoxybenzoic acid 

Downstream Products

• 110451-88-2 2-iodo-3,5-dimethoxy-4-methylbenzyl alcohol 
• 1011-27-4 3,5-dimethoxy-4-methylbenzaldehyde 
• 35047-51-9 5-(bromomethyl)-1,3-dimethoxy-2-methylbenzene 
• 100-39-0 benzyl bromide 
• 55483-02-8 alectorialin 
• 114972-99-5 2,4-dimethoxy-6-methoxymethyl-3-methylbenzoic acid 
• 114973-00-1 methyl 2,4-dimethoxy-6-methoxymethyl-3-methylbenzoate 
• 114973-01-2 methyl 6-bromomethyl-2-hydroxy-4-methoxy-3-methylbenzoate 
• 114973-02-3 methyl 6-bromomethyl-2,4-dihydroxy-3-methylbenzoate 
• 114972-98-4 3-bromo-2,6-dimethoxy-4-methoxymethyltoluene 
• 114973-11-4 4-bromomethyl-2,6-dihydroxytoluene 
• 28789-24-4 methyl alectorialate 
• 55483-01-7 5,7-Dihydroxy-6-methyl-1(3H)-isobenzofuranon 
• 187104-64-9 3,7-dimethyl-8 methoxy-6-phenylthiomethoxyisochroman 

Relevant articles and documents

Tandem Chloropalladation/Cyclization and Dearomative Cyclization toward Functionalized Tricyclic Bridged [3.2.1] Skeleton Compounds

A palladium-catalyzed tandem reaction is reported that involves chloropalladation/cyclization and dearomative cyclization to construct a tricyclic bridged [3.2.1] carbocyclic-skeleton and oxa- and aza-skeletons. In this domino process, a level of ring strain and other competitive reactions, i.e., protonolysis, β-hydride elimination, and chlorination of the C-Pd bond, were suppressed to the lowest level under mild reaction conditions.

NOVEL HETEROCYCLIC COMPOUNDS AS HSP90-INHIBITORS

Novel heterocyclic compounds are described and demonstrated to have utility as Heat Shock Protein 90 (HSP90) inhibiting agent. Method of synthesis and use of such compounds are also described.