4,5-dichloro-2-[2'-deoxy-3',5'-di-O-(4-methylbenzoyl)-β-D-erythro-pentofuranosyl]pyridazin-3(2H)-one

Base Information

• Chemical Name: 4,5-dichloro-2-[2'-deoxy-3',5'-di-O-(4-methylbenzoyl)-β-D-erythro-pentofuranosyl]pyridazin-3(2H)-one
• CAS No.: 81812-87-5
• Molecular Formula: C₂₅H₂₂Cl₂N₂O₆
• Molecular Weight: 517.365

Synonyms:4,5-dichloro-2-[2'-deoxy-3',5'-di-O-(4-methylbenzoyl)-β-D-erythro-pentofuranosyl]pyridazin-3(2H)-one

Chemical Property of 4,5-dichloro-2-[2'-deoxy-3',5'-di-O-(4-methylbenzoyl)-β-D-erythro-pentofuranosyl]pyridazin-3(2H)-one

Chemical Property:

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Technology Process of 4,5-dichloro-2-[2'-deoxy-3',5'-di-O-(4-methylbenzoyl)-β-D-erythro-pentofuranosyl]pyridazin-3(2H)-one

There total 2 articles about 4,5-dichloro-2-[2'-deoxy-3',5'-di-O-(4-methylbenzoyl)-β-D-erythro-pentofuranosyl]pyridazin-3(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

4,5-dichloro-2H-pyridazin-3-one (932-22-9) + 2-deoxy-3,5-di-O-p-toluoyl-α-D-erythro-pentofuranosyl chloride (4330-21-6) → 4,5-dichloro-2-[2'-deoxy-3',5'-di-O-(4-methylbenzoyl)-β-D-erythro-pentofuranosyl]pyridazin-3(2H)-one (81812-87-5)

Guidance literature:

4,5-dichloro-2H-pyridazin-3-one; With 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetone; for 0.166667h;

2-deoxy-3,5-di-O-p-toluoyl-α-D-erythro-pentofuranosyl chloride; In acetone; for 0.5h; Further stages.;

DOI:10.1135/cccc20060889

Reference yield: 20.0%

Hoffer's chlorosugar (3601-89-6,4330-21-6,52304-86-6,3056-12-0,141846-57-3) + 4,5-dichloro-3-trimethylsilanyloxy-pyridazine (57041-89-1) → 4,5-dichloro-2-[2'-deoxy-3',5'-di-O-(4-methylbenzoyl)-β-D-erythro-pentofuranosyl]pyridazin-3(2H)-one (81812-87-5) + 4,5-dichloro-1-(3,5-di-O-p-toluoyl-2-deoxy-α-D-erythro-pentofuranosyl)pyridazin-6-one

Guidance literature:

With tin(IV) chloride; In 1,2-dichloro-ethane; 1.) 5 deg C, 5 min, 2.) reflux, 15 min;

DOI:10.1021/jm00349a009

upstream raw materials:

Hoffer's chlorosugar

4,5-dichloro-3-trimethylsilanyloxy-pyridazine

4,5-dichloro-2H-pyridazin-3-one

2-deoxy-3,5-di-O-p-toluoyl-α-D-erythro-pentofuranosyl chloride

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