{7-[4-(1-amino-cyclobutyl)phenyl]-6-phenyl-imidazo[1,2-a]pyrimidin-5-yl}cyclopropylamine

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Chemical Name:{7-[4-(1-amino-cyclobutyl)phenyl]-6-phenyl-imidazo[1,2-a]pyrimidin-5-yl}cyclopropylamine
CAS No.:1355239-62-1
Molecular Formula:C₂₅H₂₅N₅
Molecular Weight:395.507
Hs Code.:

Synonyms:{7-[4-(1-amino-cyclobutyl)phenyl]-6-phenyl-imidazo[1,2-a]pyrimidin-5-yl}cyclopropylamine

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Chemical Property of {7-[4-(1-amino-cyclobutyl)phenyl]-6-phenyl-imidazo[1,2-a]pyrimidin-5-yl}cyclopropylamine

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Technology Process of {7-[4-(1-amino-cyclobutyl)phenyl]-6-phenyl-imidazo[1,2-a]pyrimidin-5-yl}cyclopropylamine

There total 8 articles about {7-[4-(1-amino-cyclobutyl)phenyl]-6-phenyl-imidazo[1,2-a]pyrimidin-5-yl}cyclopropylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1355240-44-6
{1-[4-(5-cyclopropylamino-6-phenyl-imidazo[1,2-a]pyrimidin-7-yl)phenyl]cyclobutyl}carbamic acid tert-butyl ester

: 1355239-62-1
{7-[4-(1-amino-cyclobutyl)phenyl]-6-phenyl-imidazo[1,2-a]pyrimidin-5-yl}cyclopropylamine

Guidance literature:: {1-[4-(5-cyclopropylamino-6-phenyl-imidazo[1,2-a]pyrimidin-7-yl)phenyl]cyclobutyl}carbamic acid tert-butyl ester; With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 120h;

With sodium hydrogencarbonate; In water; for 2h; pH=9;

Reference yield:

: 83-13-6
diethyl 2-phenylmalonate

: 1355239-62-1
{7-[4-(1-amino-cyclobutyl)phenyl]-6-phenyl-imidazo[1,2-a]pyrimidin-5-yl}cyclopropylamine

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 15 h / 100 °C

2.1: trichlorophosphate; N,N-dimethyl-aniline / 2.5 h / 100 °C

3.1: N,N-dimethyl-formamide / 0.33 h / 100 °C / microwave irradiation

4.1: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,2-dimethoxyethane; water / 0.83 h / 90 °C / microwave irradiation; Inert atmosphere

5.1: hydrogenchloride / 1,4-dioxane / 120 h / 20 °C

5.2: 2 h / pH 9

With hydrogenchloride; sodium carbonate; N,N-dimethyl-aniline; 1,8-diazabicyclo[5.4.0]undec-7-ene; trichlorophosphate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1032350-06-3
tert-butyl (1-(4-bromophenyl)cyclobutyl)carbamate

: 1355239-62-1
{7-[4-(1-amino-cyclobutyl)phenyl]-6-phenyl-imidazo[1,2-a]pyrimidin-5-yl}cyclopropylamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / tetrahydrofuran / Reflux

2.1: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,2-dimethoxyethane; water / 0.83 h / 90 °C / microwave irradiation; Inert atmosphere

3.1: hydrogenchloride / 1,4-dioxane / 120 h / 20 °C

3.2: 2 h / pH 9

With hydrogenchloride; potassium acetate; sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; water;