Technology Process of 3-benzyl-6-hydroxymethyl-3,4-dihydro-quinolin-2(1H)-one
There total 5 articles about 3-benzyl-6-hydroxymethyl-3,4-dihydro-quinolin-2(1H)-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 60 percent / N-bromosuccinimide/benzoyl peroxide / CCl4 / 5 h / Heating
2: 65 percent / sodium ethylate / ethanol
3: 50 percent / Fe powder / acetic acid / 1 h / Heating
4: 90 percent / 4N KOH / aq. ethanol / 15 h / Heating
5: 1.) Et3N, EtOCOCl; 2.) NaBH4 / 1.) THF, -5 deg C, 1 h; 25 deg C, 30 min; 2.) THF, H2O, 3 h
With
potassium hydroxide; sodium tetrahydroborate; N-Bromosuccinimide; sodium ethanolate; chloroformic acid ethyl ester; iron; triethylamine; dibenzoyl peroxide;
In
tetrachloromethane; ethanol; acetic acid;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 65 percent / sodium ethylate / ethanol
2: 50 percent / Fe powder / acetic acid / 1 h / Heating
3: 90 percent / 4N KOH / aq. ethanol / 15 h / Heating
4: 1.) Et3N, EtOCOCl; 2.) NaBH4 / 1.) THF, -5 deg C, 1 h; 25 deg C, 30 min; 2.) THF, H2O, 3 h
With
potassium hydroxide; sodium tetrahydroborate; sodium ethanolate; chloroformic acid ethyl ester; iron; triethylamine;
In
ethanol; acetic acid;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 90 percent / 4N KOH / aq. ethanol / 15 h / Heating
2: 1.) Et3N, EtOCOCl; 2.) NaBH4 / 1.) THF, -5 deg C, 1 h; 25 deg C, 30 min; 2.) THF, H2O, 3 h
With
potassium hydroxide; sodium tetrahydroborate; chloroformic acid ethyl ester; triethylamine;
In
ethanol;
