C₂₈H₅₀O₃Si₂

Base Information

• Chemical Name: C₂₈H₅₀O₃Si₂
• CAS No.: 1286188-88-2
• Molecular Formula: C₂₈H₅₀O₃Si₂
• Molecular Weight: 490.874
• Mol file: 1286188-88-2.mol

Synonyms:C₂₈H₅₀O₃Si₂

Chemical Property of C₂₈H₅₀O₃Si₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₈H₅₀O₃Si₂

There total 1 articles about C₂₈H₅₀O₃Si₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-4-{(3S,4R)-4-(tert-Butyl-dimethyl-silanyloxy)-3-[2-(dimethyl-phenyl-silanyl)-ethyl]-6-methylene-cyclohex-1-enyl}-pentanoic acid (828915-85-1) → C28H50O3Si2 (1286188-88-2)

Guidance literature:

(S)-4-{(3S,4R)-4-(tert-Butyl-dimethyl-silanyloxy)-3-[2-(dimethyl-phenyl-silanyl)-ethyl]-6-methylene-cyclohex-1-enyl}-pentanoic acid; With bis(2,4,6-trimethylpyridine)iodine(I) hexafluorophosphate; In toluene; at 0 - 20 ℃; for 15h; Darkness;

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; at 75 ℃; for 2.25h;

With lithium borohydride; In tetrahydrofuran; at 0 - 20 ℃;

DOI:10.1002/chem.201002927

Reference yield: 100.0%

C28H50O3Si2 (1286188-88-2) + trityl chloride (76-83-5) → C47H64O3Si2 (1286188-90-6)

Guidance literature:

With pyridine; dmap; In dichloromethane; at 20 ℃; for 12h; chemoselective reaction;

DOI:10.1002/chem.201002927

Reference yield:

C28H50O3Si2 (1286188-88-2) → C37H44O4Si

Guidance literature:

Multi-step reaction with 8 steps

1.1: pyridine; dmap / dichloromethane / 12 h / 20 °C

2.1: pyridine; Dess-Martin periodane / dichloromethane / 12 h / 20 °C / Darkness

3.1: tetrabutyl ammonium fluoride; acetic acid / tetrahydrofuran / 15 h / 20 °C

4.1: sodium bis(2-methoxyethoxy)aluminium dihydride / dichloromethane; toluene / -20 - 20 °C

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 8 h / 85 °C / Molecular sieve; Sealed tube

5.2: 1 h / 85 °C / Sealed tube

6.1: N-chloro-succinimide; 4-oxo-2,2,6,6-tetramethylpiperidin-oxyl; tetrabutyl-ammonium chloride; sodium hydrogencarbonate; potassium carbonate / dichloromethane; water / 1.5 h / 20 °C / pH 8.6

7.1: 1H-imidazole / dichloromethane / 0.5 h / 0 °C

8.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / 20 °C

With pyridine; 1H-imidazole; dmap; N-chloro-succinimide; 4-oxo-2,2,6,6-tetramethylpiperidin-oxyl; tetrabutyl ammonium fluoride; tetrabutyl-ammonium chloride; sodium hydride; sodium hydrogencarbonate; potassium carbonate; Dess-Martin periodane; acetic acid; sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; toluene; mineral oil; 2.1: Dess-Martin oxidation;

DOI:10.1002/chem.201002927

upstream raw materials:

(S)-4-{(3S,4R)-4-(tert-Butyl-dimethyl-silanyloxy)-3-[2-(dimethyl-phenyl-silanyl)-ethyl]-6-methylene-cyclohex-1-enyl}-pentanoic acid

Downstream raw materials:

C₄₁H₄₈O₃Si

C₄₁H₅₀O₃Si

C₃₃H₄₀O₄

C₃₃H₃₆O₄