N-{4-[(3,4,6-tri-O-acetyl-2-deoxy-2-fluoro-β-D-glucopyranosyl)amino]-4-oxobutyl}-4-{4-[bis(2-chloroethyl)amino]phenyl}butanamide

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Chemical Name:N-{4-[(3,4,6-tri-O-acetyl-2-deoxy-2-fluoro-β-D-glucopyranosyl)amino]-4-oxobutyl}-4-{4-[bis(2-chloroethyl)amino]phenyl}butanamide
CAS No.:1001406-77-4
Molecular Formula:C₃₀H₄₂Cl₂FN₃O₉
Molecular Weight:678.583
Hs Code.:

Synonyms:N-{4-[(3,4,6-tri-O-acetyl-2-deoxy-2-fluoro-β-D-glucopyranosyl)amino]-4-oxobutyl}-4-{4-[bis(2-chloroethyl)amino]phenyl}butanamide

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Chemical Property of N-{4-[(3,4,6-tri-O-acetyl-2-deoxy-2-fluoro-β-D-glucopyranosyl)amino]-4-oxobutyl}-4-{4-[bis(2-chloroethyl)amino]phenyl}butanamide

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Technology Process of N-{4-[(3,4,6-tri-O-acetyl-2-deoxy-2-fluoro-β-D-glucopyranosyl)amino]-4-oxobutyl}-4-{4-[bis(2-chloroethyl)amino]phenyl}butanamide

There total 7 articles about N-{4-[(3,4,6-tri-O-acetyl-2-deoxy-2-fluoro-β-D-glucopyranosyl)amino]-4-oxobutyl}-4-{4-[bis(2-chloroethyl)amino]phenyl}butanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

: 4-amino-N-(3,4,6-tri-O-acetyl-2-deoxy-2-fluoro-β-D-glucopyranosyl)butanamide

: 1001406-77-4
N-{4-[(3,4,6-tri-O-acetyl-2-deoxy-2-fluoro-β-D-glucopyranosyl)amino]-4-oxobutyl}-4-{4-[bis(2-chloroethyl)amino]phenyl}butanamide

Guidance literature:: chlorambucil; With chloroformic acid ethyl ester; triethylamine; In dichloromethane; at 0 - 20 ℃; for 0.5h;

4-amino-N-(3,4,6-tri-O-acetyl-2-deoxy-2-fluoro-β-D-glucopyranosyl)butanamide; In dichloromethane; at 20 ℃; for 48h;

Reference yield: 24.0%

: 4-amino-N-(3,4,6-tri-O-acetyl-2-deoxy-2-fluoro-β-D-glucopyranosyl)butanamide

: 305-03-3
chlorambucil

: 1001406-77-4
N-{4-[(3,4,6-tri-O-acetyl-2-deoxy-2-fluoro-β-D-glucopyranosyl)amino]-4-oxobutyl}-4-{4-[bis(2-chloroethyl)amino]phenyl}butanamide

Guidance literature:: 4-amino-N-(3,4,6-tri-O-acetyl-2-deoxy-2-fluoro-β-D-glucopyranosyl)butanamide; With chloroformic acid ethyl ester; triethylamine; In dichloromethane; at 20 ℃;

chlorambucil; In dichloromethane; at 20 ℃; Further stages.;
DOI:10.1016/j.bmc.2008.03.038

Reference yield:

: N-(3,4,6-tri-O-acetyl-2-deoxy-2-fluoro-β-D-glucopyranosyl)-4-azidobutanamide

: 1001406-77-4
N-{4-[(3,4,6-tri-O-acetyl-2-deoxy-2-fluoro-β-D-glucopyranosyl)amino]-4-oxobutyl}-4-{4-[bis(2-chloroethyl)amino]phenyl}butanamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogen / palladium 10% on activated carbon / methanol; dichloromethane / 7 h / 760.05 Torr

2.1: chloroformic acid ethyl ester; triethylamine / dichloromethane / 0.5 h / 0 - 20 °C

2.2: 48 h / 20 °C

With hydrogen; chloroformic acid ethyl ester; triethylamine; palladium 10% on activated carbon; In methanol; dichloromethane;