(benzhydrylidene-amino)-(tetrahydro-pyran-4-yl)-acetic acid ethyl ester

Base Information

• Chemical Name: (benzhydrylidene-amino)-(tetrahydro-pyran-4-yl)-acetic acid ethyl ester
• CAS No.: 921755-39-7
• Molecular Formula: C₂₂H₂₅NO₃
• Molecular Weight: 351.445
• Mol file: 921755-39-7.mol

Synonyms:(benzhydrylidene-amino)-(tetrahydro-pyran-4-yl)-acetic acid ethyl ester

Chemical Property of (benzhydrylidene-amino)-(tetrahydro-pyran-4-yl)-acetic acid ethyl ester

Chemical Property:

Purity/Quality:

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Technology Process of (benzhydrylidene-amino)-(tetrahydro-pyran-4-yl)-acetic acid ethyl ester

There total 1 articles about (benzhydrylidene-amino)-(tetrahydro-pyran-4-yl)-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

4-iodotetrahydropyran (25637-18-7) + ethyl N-diphenylmethylene glycine (69555-14-2) → (benzhydrylidene-amino)-(tetrahydro-pyran-4-yl)-acetic acid ethyl ester (921755-39-7)

Guidance literature:

ethyl N-diphenylmethylene glycine; With n-butyllithium; diisopropylamine; In tetrahydrofuran; at 78 ℃; for 0.75h;

4-iodotetrahydropyran; In tetrahydrofuran; at 20 ℃;

DOI:10.1021/jo061977a

Reference yield: 91.0%

(benzhydrylidene-amino)-(tetrahydro-pyran-4-yl)-acetic acid ethyl ester (921755-39-7) → ethyl aminotetrahydropyran-4-ylacetate (646055-93-8)

Guidance literature:

With hydrogenchloride; for 0.5h;

DOI:10.1021/jo061977a

upstream raw materials:

4-iodotetrahydropyran

ethyl N-diphenylmethylene glycine

Downstream raw materials:

ethyl aminotetrahydropyran-4-ylacetate