N₂-(3,5-dimorpholinophenyl)-N₄-isopropyl-N₂-(4-methoxybenzyl)-N₄-(3-methoxyphenyl)pyrimidine-2,4-diamine

Base Information

• Chemical Name: N₂-(3,5-dimorpholinophenyl)-N₄-isopropyl-N₂-(4-methoxybenzyl)-N₄-(3-methoxyphenyl)pyrimidine-2,4-diamine
• CAS No.: 1051899-65-0
• Molecular Formula: C₃₆H₄₄N₆O₄
• Molecular Weight: 624.783

Synonyms:N₂-(3,5-dimorpholinophenyl)-N₄-isopropyl-N₂-(4-methoxybenzyl)-N₄-(3-methoxyphenyl)pyrimidine-2,4-diamine

Chemical Property of N₂-(3,5-dimorpholinophenyl)-N₄-isopropyl-N₂-(4-methoxybenzyl)-N₄-(3-methoxyphenyl)pyrimidine-2,4-diamine

Chemical Property:

Purity/Quality:

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Technology Process of N₂-(3,5-dimorpholinophenyl)-N₄-isopropyl-N₂-(4-methoxybenzyl)-N₄-(3-methoxyphenyl)pyrimidine-2,4-diamine

There total 7 articles about N₂-(3,5-dimorpholinophenyl)-N₄-isopropyl-N₂-(4-methoxybenzyl)-N₄-(3-methoxyphenyl)pyrimidine-2,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

isopropyl chloride (75-29-6) + N2-(3,5-dimorpholinophenyl)-N2-(4-methoxybenzyl)-N4-(3-methoxyphenyl)pyrimidine-2,4-diamine (1051899-64-9) → N2-(3,5-dimorpholinophenyl)-N4-isopropyl-N2-(4-methoxybenzyl)-N4-(3-methoxyphenyl)pyrimidine-2,4-diamine (1051899-65-0)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 25 - 90 ℃; for 21h;

Reference yield:

4,4’-(5-nitro-1,3-phenylene)dimorpholine (220954-17-6) → N2-(3,5-dimorpholinophenyl)-N4-isopropyl-N2-(4-methoxybenzyl)-N4-(3-methoxyphenyl)pyrimidine-2,4-diamine (1051899-65-0)

Guidance literature:

Multi-step reaction with 6 steps

1.1: hydrogen / palladium 10% on activated carbon / ethanol / 17 h / 20 °C / 760.05 Torr

2.1: 3 h / Heating / reflux

3.1: sodium hydride / tetrahydrofuran / 0.25 h / 0 - 20 °C

3.2: 0 - 20 °C

3.3: 1 h

4.1: sodium hydride / tetrahydrofuran / 2 h / 0 - 20 °C

4.2: 15 h / 20 °C

5.1: isopropyl alcohol / 1 h / 80 °C

6.1: sodium hydride / N,N-dimethyl-formamide / 21 h / 25 - 90 °C

With hydrogen; sodium hydride; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

1,3-difluoro-5-nitrobenzene (2265-94-3) → N2-(3,5-dimorpholinophenyl)-N4-isopropyl-N2-(4-methoxybenzyl)-N4-(3-methoxyphenyl)pyrimidine-2,4-diamine (1051899-65-0)

Guidance literature:

Multi-step reaction with 7 steps

1.1: dimethyl sulfoxide / 90 h / 160 °C

2.1: hydrogen / palladium 10% on activated carbon / ethanol / 17 h / 20 °C / 760.05 Torr

3.1: 3 h / Heating / reflux

4.1: sodium hydride / tetrahydrofuran / 0.25 h / 0 - 20 °C

4.2: 0 - 20 °C

4.3: 1 h

5.1: sodium hydride / tetrahydrofuran / 2 h / 0 - 20 °C

5.2: 15 h / 20 °C

6.1: isopropyl alcohol / 1 h / 80 °C

7.1: sodium hydride / N,N-dimethyl-formamide / 21 h / 25 - 90 °C

With hydrogen; sodium hydride; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide; isopropyl alcohol;

upstream raw materials:

isopropyl chloride

N₂-(3,5-dimorpholinophenyl)-N₂-(4-methoxybenzyl)-N₄-(3-methoxyphenyl)pyrimidine-2,4-diamine

3,5-di(morpholino)aniline

N-(3,5-dimorpholin-4-ylphenyl)formamide

Downstream raw materials:

N₂-(3,5-dimorpholinophenyl)-N₄-isopropyl-N₄-(3-methoxyphenyl)pyrimidine-2,4-diamine

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