N-tert-butoxycarbonyl-D-phenylalanyl-L-cysteinyl(Acm)-D-tryptophyl-L-leucine

Base Information

Chemical Name:N-tert-butoxycarbonyl-D-phenylalanyl-L-cysteinyl(Acm)-D-tryptophyl-L-leucine
CAS No.:128633-35-2
Molecular Formula:C₃₇H₅₀N₆O₈S
Molecular Weight:738.905
Hs Code.:

Synonyms:N-tert-butoxycarbonyl-D-phenylalanyl-L-cysteinyl(Acm)-D-tryptophyl-L-leucine

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Chemical Property of N-tert-butoxycarbonyl-D-phenylalanyl-L-cysteinyl(Acm)-D-tryptophyl-L-leucine

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Technology Process of N-tert-butoxycarbonyl-D-phenylalanyl-L-cysteinyl(Acm)-D-tryptophyl-L-leucine

There total 8 articles about N-tert-butoxycarbonyl-D-phenylalanyl-L-cysteinyl(Acm)-D-tryptophyl-L-leucine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 128632-71-3
N-tert-butoxycarbonyl-D-phenylalanyl-L-cysteinyl(Acm)-D-tryptophyl-L-leucine methyl ester

: 128633-35-2
N-tert-butoxycarbonyl-D-phenylalanyl-L-cysteinyl(Acm)-D-tryptophyl-L-leucine

Guidance literature:: With sodium hydroxide; In methanol; for 2h; Ambient temperature;

Reference yield:

: 18942-49-9
Boc-D-Phe-OH

: 128633-35-2
N-tert-butoxycarbonyl-D-phenylalanyl-L-cysteinyl(Acm)-D-tryptophyl-L-leucine

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N, 1-hydroxybenzotriazole (HOBt), dicyclohexylcarbodiimide (DCCI) / dimethylformamide / 4 °C

2: 95 percent / aq. NaOH / methanol / 2 h / Ambient temperature

With sodium hydroxide; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In methanol; N,N-dimethyl-formamide;

Reference yield:

: 7517-19-3
methyl (L)-leucinate hydrochloride

: 128633-35-2
N-tert-butoxycarbonyl-D-phenylalanyl-L-cysteinyl(Acm)-D-tryptophyl-L-leucine

Guidance literature:: Multi-step reaction with 6 steps

1: 85.9 percent / dicyclohexylcarbodiimide (DCCI), 1-hydroxybenzotriazole (HOBt), Et₃N / dimethylformamide / 4 °C

2: 83.6 percent / 6N HCl, dithioethane / ethyl acetate / 1 h

3: 89.7 percent / Et₃N / dimethylformamide / Ambient temperature

4: 3N HCl / ethyl acetate

5: Et₃N, 1-hydroxybenzotriazole (HOBt), dicyclohexylcarbodiimide (DCCI) / dimethylformamide / 4 °C

6: 95 percent / aq. NaOH / methanol / 2 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; benzotriazol-1-ol; ethane-1,2-dithiol; triethylamine; dicyclohexyl-carbodiimide; In methanol; ethyl acetate; N,N-dimethyl-formamide;