4-(2-(3,4-bis-difluoromethoxy-phenyl)-2-{4-[2,2,2-trifluoro-1-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-phenyl}-ethyl)-3-triisopropylsilanyloxymethyl-pyridine

Base Information

Chemical Name:4-(2-(3,4-bis-difluoromethoxy-phenyl)-2-{4-[2,2,2-trifluoro-1-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-phenyl}-ethyl)-3-triisopropylsilanyloxymethyl-pyridine
CAS No.:524775-30-2
Molecular Formula:C₄₀H₅₃F₁₀NO₅Si₂
Molecular Weight:874.02
Hs Code.:

4-(2-(3,4-bis-difluoromethoxy-phenyl)-2-{4-[2,2,2-trifluoro-1-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-phenyl}-ethyl)-3-triisopropylsilanyloxymethyl-pyridine

Synonyms:4-(2-(3,4-bis-difluoromethoxy-phenyl)-2-{4-[2,2,2-trifluoro-1-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-phenyl}-ethyl)-3-triisopropylsilanyloxymethyl-pyridine

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Chemical Property of 4-(2-(3,4-bis-difluoromethoxy-phenyl)-2-{4-[2,2,2-trifluoro-1-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-phenyl}-ethyl)-3-triisopropylsilanyloxymethyl-pyridine

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Technology Process of 4-(2-(3,4-bis-difluoromethoxy-phenyl)-2-{4-[2,2,2-trifluoro-1-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-phenyl}-ethyl)-3-triisopropylsilanyloxymethyl-pyridine

There total 13 articles about 4-(2-(3,4-bis-difluoromethoxy-phenyl)-2-{4-[2,2,2-trifluoro-1-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-phenyl}-ethyl)-3-triisopropylsilanyloxymethyl-pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 80522-42-5
triisopropylsilyl trifluoromethanesulfonate

: 524775-30-2
4-(2-(3,4-bis-difluoromethoxy-phenyl)-2-{4-[2,2,2-trifluoro-1-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-phenyl}-ethyl)-3-triisopropylsilanyloxymethyl-pyridine

Guidance literature:: Multi-step reaction with 4 steps

1.1: 2,6-lutidine / CH₂Cl₂ / 2 h / -78 - 20 °C

2.1: LDA; HMPA / tetrahydrofuran / 0.33 h / -78 °C

2.2: 76 percent / HMPA / tetrahydrofuran / 0.5 h / -78 - 0 °C

3.1: KHMDS; HMPA / tetrahydrofuran / 0.5 h / 20 °C

3.2: HMPA / tetrahydrofuran / 18 h / 55 °C

4.1: 2N aq. LiOH / tetrahydrofuran; methanol / 18 h / 50 °C

4.2: 4N aq. HCl

With 2,6-dimethylpyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; lithium hydroxide; potassium hexamethylsilazane; lithium diisopropyl amide; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/S0960-894X(02)00615-7

Reference yield:

: 3-(3,4-bis-difluoromethoxy-phenyl)-3-{4-[2,2,2-trifluoro-1-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-phenyl}-2-(3-triisopropylsilanyloxymethyl-pyridin-4-yl)-propionic acid methyl ester

: 524775-30-2
4-(2-(3,4-bis-difluoromethoxy-phenyl)-2-{4-[2,2,2-trifluoro-1-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-phenyl}-ethyl)-3-triisopropylsilanyloxymethyl-pyridine

Guidance literature:: 3-(3,4-bis-difluoromethoxy-phenyl)-3-{4-[2,2,2-trifluoro-1-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-phenyl}-2-(3-triisopropylsilanyloxymethyl-pyridin-4-yl)-propionic acid methyl ester; With lithium hydroxide; In tetrahydrofuran; methanol; at 50 ℃; for 18h;

With hydrogenchloride;
DOI:10.1016/S0960-894X(02)00615-7

Reference yield:

: 4664-27-1
(4-methylpyridin-3-yl)methanol

: 524775-30-2
4-(2-(3,4-bis-difluoromethoxy-phenyl)-2-{4-[2,2,2-trifluoro-1-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-phenyl}-ethyl)-3-triisopropylsilanyloxymethyl-pyridine

Guidance literature:: Multi-step reaction with 4 steps

1.1: 2,6-lutidine / CH₂Cl₂ / 2 h / -78 - 20 °C

2.1: LDA; HMPA / tetrahydrofuran / 0.33 h / -78 °C

2.2: 76 percent / HMPA / tetrahydrofuran / 0.5 h / -78 - 0 °C

3.1: KHMDS; HMPA / tetrahydrofuran / 0.5 h / 20 °C

3.2: HMPA / tetrahydrofuran / 18 h / 55 °C

4.1: 2N aq. LiOH / tetrahydrofuran; methanol / 18 h / 50 °C

4.2: 4N aq. HCl

With 2,6-dimethylpyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; lithium hydroxide; potassium hexamethylsilazane; lithium diisopropyl amide; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/S0960-894X(02)00615-7