methyl 8-(benzyloxy)-7-bromo-2-(2'-aminophenyl)quinoline-5'-carboxylate

Base Information

• Chemical Name: methyl 8-(benzyloxy)-7-bromo-2-(2'-aminophenyl)quinoline-5'-carboxylate
• CAS No.: 110144-35-9
• Molecular Formula: C₂₄H₁₉BrN₂O₃
• Molecular Weight: 463.33
• Mol file: 110144-35-9.mol

Synonyms:methyl 8-(benzyloxy)-7-bromo-2-(2'-aminophenyl)quinoline-5'-carboxylate

Chemical Property of methyl 8-(benzyloxy)-7-bromo-2-(2'-aminophenyl)quinoline-5'-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of methyl 8-(benzyloxy)-7-bromo-2-(2'-aminophenyl)quinoline-5'-carboxylate

There total 1 articles about methyl 8-(benzyloxy)-7-bromo-2-(2'-aminophenyl)quinoline-5'-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

2-Amino-3-(benzyloxy)-4-bromobenzaldehyde (99573-20-3) + 3-acetyl-4-aminobenzoic acid methyl ester (111714-47-7) → methyl 8-(benzyloxy)-7-bromo-2-(2'-aminophenyl)quinoline-5'-carboxylate (110144-35-9)

Guidance literature:

With N-benzyl-trimethylammonium hydroxide; In tetrahydrofuran; methanol; at 0 - 25 ℃; for 6h;

DOI:10.1021/jm00393a040

Reference yield: 87.0%

methyl 8-(benzyloxy)-7-bromo-2-(2'-aminophenyl)quinoline-5'-carboxylate (110144-35-9) → methyl 7-bromo-8-hydroxy-2-(2'-aminophenyl)quinoline-5'-carboxylate (110144-36-0)

Guidance literature:

With hydrogen bromide; In dichloromethane; at 60 ℃; for 10h;

DOI:10.1021/jm00393a040

Reference yield:

methyl 8-(benzyloxy)-7-bromo-2-(2'-aminophenyl)quinoline-5'-carboxylate (110144-35-9) → methyl 7-bromo-2-(2'-aminophenyl)-5,8-dioxoquinoline-5'-carboxylate (110144-37-1)

Guidance literature:

With phosphate buffer; potassium nitrososulfate; tetra(n-butyl)ammonium hydrogensulfate; In dichloromethane; at 25 ℃; for 20h;

DOI:10.1021/jm00393a040

upstream raw materials:

2-Amino-3-(benzyloxy)-4-bromobenzaldehyde

3-acetyl-4-aminobenzoic acid methyl ester

Downstream raw materials:

methyl 7-bromo-8-hydroxy-2-(2'-aminophenyl)quinoline-5'-carboxylate

methyl 7-bromo-2-(2'-aminophenyl)-5,8-dioxoquinoline-5'-carboxylate

7-amino-2-(2'-aminophenyl)-5,8-dioxoquinoline-5'-carboxylic acid

methyl 7-amino-2-(2'-aminophenyl)-5,8-dioxoquinoline-5'-carboxylate