[(2R,3R,4S,5R,6S)-3,4,5-tribenzyloxy-6-[4-chloro-3-[[4-(trifluoromethoxy)phenyl]methyl]phenyl]-6-methoxy-tetrahydropyran-2-yl]methanol

Base Information

Chemical Name:[(2R,3R,4S,5R,6S)-3,4,5-tribenzyloxy-6-[4-chloro-3-[[4-(trifluoromethoxy)phenyl]methyl]phenyl]-6-methoxy-tetrahydropyran-2-yl]methanol
CAS No.:1358580-89-8
Molecular Formula:C₄₂H₄₀ClF₃O₇
Molecular Weight:749.224
Hs Code.:

Synonyms:[(2R,3R,4S,5R,6S)-3,4,5-tribenzyloxy-6-[4-chloro-3-[[4-(trifluoromethoxy)phenyl]methyl]phenyl]-6-methoxy-tetrahydropyran-2-yl]methanol

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Chemical Property of [(2R,3R,4S,5R,6S)-3,4,5-tribenzyloxy-6-[4-chloro-3-[[4-(trifluoromethoxy)phenyl]methyl]phenyl]-6-methoxy-tetrahydropyran-2-yl]methanol

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Technology Process of [(2R,3R,4S,5R,6S)-3,4,5-tribenzyloxy-6-[4-chloro-3-[[4-(trifluoromethoxy)phenyl]methyl]phenyl]-6-methoxy-tetrahydropyran-2-yl]methanol

There total 15 articles about [(2R,3R,4S,5R,6S)-3,4,5-tribenzyloxy-6-[4-chloro-3-[[4-(trifluoromethoxy)phenyl]methyl]phenyl]-6-methoxy-tetrahydropyran-2-yl]methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.7%

: 1358580-87-6
[[(2R,3R,4S,5R,6S)-3,4,5-tribenzyloxy-6-[4-chloro-3-[[4-(trifluoromethoxy)phenyl]methyl]phenyl]-6-methoxy-tetrahydropyran-2-yl]methoxy]tert-butyl-dimethyl-silane

: 1358580-89-8
[(2R,3R,4S,5R,6S)-3,4,5-tribenzyloxy-6-[4-chloro-3-[[4-(trifluoromethoxy)phenyl]methyl]phenyl]-6-methoxy-tetrahydropyran-2-yl]methanol

Guidance literature:: With methanol; acetyl chloride; for 1.5h;

Reference yield:

: 21739-92-4
5-bromo-2-chlorobenzoic acid

: 1358580-89-8
[(2R,3R,4S,5R,6S)-3,4,5-tribenzyloxy-6-[4-chloro-3-[[4-(trifluoromethoxy)phenyl]methyl]phenyl]-6-methoxy-tetrahydropyran-2-yl]methanol

Guidance literature:: Multi-step reaction with 8 steps

1.1: triethylamine / dichloromethane / 16 h

2.1: tetrahydrofuran / 2 h

3.1: sodium tetrahydroborate; methanol / tetrahydrofuran / 0.5 h / 0 °C

4.1: boron trifluoride diethyl etherate; triethylsilane / dichloromethane / 16 h

5.1: n-butyllithium / tetrahydrofuran; hexane / 1.5 h / -78 °C

5.2: 2 h / -78 °C

5.3: 16 h / 20 °C

6.1: pyridine; dmap / 16 h

7.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 - 20 °C

7.2: 16 h

8.1: acetyl chloride; methanol / 1.5 h

With pyridine; methanol; triethylsilane; dmap; sodium tetrahydroborate; n-butyllithium; boron trifluoride diethyl etherate; sodium hydride; triethylamine; acetyl chloride; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1181681-65-1
4-bromo-1-chloro-2-[[4-(trifluoromethoxy)phenyl]methyl]benzene

: 1358580-89-8
[(2R,3R,4S,5R,6S)-3,4,5-tribenzyloxy-6-[4-chloro-3-[[4-(trifluoromethoxy)phenyl]methyl]phenyl]-6-methoxy-tetrahydropyran-2-yl]methanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 1.5 h / -78 °C

1.2: 2 h / -78 °C

1.3: 16 h / 20 °C

2.1: pyridine; dmap / 16 h

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 - 20 °C

3.2: 16 h

4.1: acetyl chloride; methanol / 1.5 h

With pyridine; methanol; dmap; n-butyllithium; sodium hydride; acetyl chloride; In tetrahydrofuran; hexane; N,N-dimethyl-formamide; mineral oil;