hexa-tert-butyl N-(4-aminobenzoyl)-γ-L-glutamyl-γ-L-glutamyl-γ-L-glutamyl-γ-L-glutamyl-L-glutamate

Base Information

Chemical Name:hexa-tert-butyl N-(4-aminobenzoyl)-γ-L-glutamyl-γ-L-glutamyl-γ-L-glutamyl-γ-L-glutamyl-L-glutamate
CAS No.:117559-44-1
Molecular Formula:C₅₆H₉₀N₆O₁₇
Molecular Weight:1119.36
Hs Code.:

Synonyms:hexa-tert-butyl N-(4-aminobenzoyl)-γ-L-glutamyl-γ-L-glutamyl-γ-L-glutamyl-γ-L-glutamyl-L-glutamate

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Chemical Property of hexa-tert-butyl N-(4-aminobenzoyl)-γ-L-glutamyl-γ-L-glutamyl-γ-L-glutamyl-γ-L-glutamyl-L-glutamate

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Technology Process of hexa-tert-butyl N-(4-aminobenzoyl)-γ-L-glutamyl-γ-L-glutamyl-γ-L-glutamyl-γ-L-glutamyl-L-glutamate

There total 15 articles about hexa-tert-butyl N-(4-aminobenzoyl)-γ-L-glutamyl-γ-L-glutamyl-γ-L-glutamyl-γ-L-glutamyl-L-glutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 133042-46-3
hexa-tert-butyl N-(4-nitrobenzoyl)-γ-L-glutamyl-γ-L-glutamyl-γ-L-glutamyl-γ-L-glutamyl-L-glutamate

: 117559-44-1
hexa-tert-butyl N-(4-aminobenzoyl)-γ-L-glutamyl-γ-L-glutamyl-γ-L-glutamyl-γ-L-glutamyl-L-glutamate

Guidance literature:: With hydrogen; platinum(IV) oxide; In ethanol; acetic acid; for 2h; under 2482.3 Torr;
DOI:10.1021/jo00010a038

Reference yield:

: 32719-57-6
tetra-tert-butyl N--L-γ-glutamyl>-L-glutamate

: 117559-44-1
hexa-tert-butyl N-(4-aminobenzoyl)-γ-L-glutamyl-γ-L-glutamyl-γ-L-glutamyl-γ-L-glutamyl-L-glutamate

Guidance literature:: Multi-step reaction with 7 steps

1: H₂ / 10percent Pd/C / methanol

2: 1) N-methylmorpholine, isobutylchloroformate / 1) THF, -20 deg C, 10 min, 2) THF, -20 deg C, 10 min

3: H₂ / 10percent Pd/C / methanol

4: 1) N-methylmorpholine, isobutylchloroformate / 1) THF, -20 deg C, 10 min, 2) THF, -20 deg C, 10 min

5: H₂ / 10percent Pd/C / methanol

6: 72 percent / N-methylmorpholine / dioxane / 0.33 h / Ambient temperature

7: H₂ / 10percent Pd/C / methanol / 1 h

With 4-methyl-morpholine; hydrogen; isobutyl chloroformate; palladium on activated charcoal; In 1,4-dioxane; methanol;
DOI:10.1021/jm00121a029

Reference yield:

: 88063-78-9
L-γ-glutamyl-L-glutamic acid tris-t-butyl ester

: 117559-44-1
hexa-tert-butyl N-(4-aminobenzoyl)-γ-L-glutamyl-γ-L-glutamyl-γ-L-glutamyl-γ-L-glutamyl-L-glutamate

Guidance literature:: Multi-step reaction with 8 steps

1: 1) N-methylmorpholine, isobutylchloroformate / 1) THF, -20 deg C, 10 min, 2) THF, -20 deg C, 10 min

2: H₂ / 10percent Pd/C / methanol

3: 1) N-methylmorpholine, isobutylchloroformate / 1) THF, -20 deg C, 10 min, 2) THF, -20 deg C, 10 min

4: H₂ / 10percent Pd/C / methanol

5: 1) N-methylmorpholine, isobutylchloroformate / 1) THF, -20 deg C, 10 min, 2) THF, -20 deg C, 10 min

6: H₂ / 10percent Pd/C / methanol

7: 72 percent / N-methylmorpholine / dioxane / 0.33 h / Ambient temperature

8: H₂ / 10percent Pd/C / methanol / 1 h

With 4-methyl-morpholine; hydrogen; isobutyl chloroformate; palladium on activated charcoal; In 1,4-dioxane; methanol;
DOI:10.1021/jm00121a029