hexa-tert-butyl N-(4-nitrobenzoyl)-γ-L-glutamyl-γ-L-glutamyl-γ-L-glutamyl-γ-L-glutamyl-L-glutamate

Base Information

Chemical Name:hexa-tert-butyl N-(4-nitrobenzoyl)-γ-L-glutamyl-γ-L-glutamyl-γ-L-glutamyl-γ-L-glutamyl-L-glutamate
CAS No.:133042-46-3
Molecular Formula:C₅₆H₈₈N₆O₁₉
Molecular Weight:1149.34
Hs Code.:

Synonyms:hexa-tert-butyl N-(4-nitrobenzoyl)-γ-L-glutamyl-γ-L-glutamyl-γ-L-glutamyl-γ-L-glutamyl-L-glutamate

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Chemical Property of hexa-tert-butyl N-(4-nitrobenzoyl)-γ-L-glutamyl-γ-L-glutamyl-γ-L-glutamyl-γ-L-glutamyl-L-glutamate

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Technology Process of hexa-tert-butyl N-(4-nitrobenzoyl)-γ-L-glutamyl-γ-L-glutamyl-γ-L-glutamyl-γ-L-glutamyl-L-glutamate

There total 8 articles about hexa-tert-butyl N-(4-nitrobenzoyl)-γ-L-glutamyl-γ-L-glutamyl-γ-L-glutamyl-γ-L-glutamyl-L-glutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 73167-56-3
L-γ-glutamyl-L-γ-glutamyl-L-γ-glutamyl-L-glutamyl-L-glutamic acid hexakis-t-butyl ester

: 122-04-3
4-nitro-benzoyl chloride

: 133042-46-3
hexa-tert-butyl N-(4-nitrobenzoyl)-γ-L-glutamyl-γ-L-glutamyl-γ-L-glutamyl-γ-L-glutamyl-L-glutamate

Guidance literature:: With 4-methyl-morpholine; In dichloromethane; at 25 ℃; for 1.5h;
DOI:10.1021/jo00010a038

Reference yield:

: 16874-06-9
di-tert-butyl L-glutamate

: 133042-46-3
hexa-tert-butyl N-(4-nitrobenzoyl)-γ-L-glutamyl-γ-L-glutamyl-γ-L-glutamyl-γ-L-glutamyl-L-glutamate

Guidance literature:: Multi-step reaction with 9 steps

1: (PhO)2P(=O)N₃

2: 76 percent / H₂ / Pd/C / methanol; acetic acid / 1.5 h / 2585.7 Torr

3: (PhO)2P(=O)N₃

4: 98 percent / H₂ / Pd/C / methanol; acetic acid / 1.5 h / 2585.7 Torr

5: (PhO)2P(=O)N₃

6: 88 percent / H₂ / Pd/C / methanol; acetic acid / 1.5 h / 2585.7 Torr

7: (PhO)2P(=O)N₃

8: 98 percent / H₂ / Pd/C / methanol; acetic acid / 1.5 h / 2585.7 Torr

9: 97 percent / N-methylmorpholine / CH₂Cl₂ / 1.5 h / 25 °C

With 4-methyl-morpholine; diphenyl phosphoryl azide; hydrogen; palladium on activated charcoal; In methanol; dichloromethane; acetic acid;
DOI:10.1021/jo00010a038

Reference yield:

: 32719-57-6
tetra-tert-butyl N--L-γ-glutamyl>-L-glutamate

: 133042-46-3
hexa-tert-butyl N-(4-nitrobenzoyl)-γ-L-glutamyl-γ-L-glutamyl-γ-L-glutamyl-γ-L-glutamyl-L-glutamate

Guidance literature:: Multi-step reaction with 6 steps

1: 98 percent / H₂ / Pd/C / methanol; acetic acid / 1.5 h / 2585.7 Torr

2: (PhO)2P(=O)N₃

3: 88 percent / H₂ / Pd/C / methanol; acetic acid / 1.5 h / 2585.7 Torr

4: (PhO)2P(=O)N₃

5: 98 percent / H₂ / Pd/C / methanol; acetic acid / 1.5 h / 2585.7 Torr

6: 97 percent / N-methylmorpholine / CH₂Cl₂ / 1.5 h / 25 °C

With 4-methyl-morpholine; diphenyl phosphoryl azide; hydrogen; palladium on activated charcoal; In methanol; dichloromethane; acetic acid;
DOI:10.1021/jo00010a038